M
Matthew J. Fuchter
Researcher at Imperial College London
Publications - 159
Citations - 6834
Matthew J. Fuchter is an academic researcher from Imperial College London. The author has contributed to research in topics: Chemistry & Medicine. The author has an hindex of 36, co-authored 134 publications receiving 4871 citations. Previous affiliations of Matthew J. Fuchter include Emory University & University of London.
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Journal ArticleDOI
Design, synthesis and initial characterisation of a radiolabelled [18F]pyrimidoindolone probe for detecting activated caspase-3/7
A. Udemba,Graham Smith,Quang-Dé Nguyen,Maciej Kaliszczak,Laurence Carroll,Robin Fortt,Matthew J. Fuchter,Eric O. Aboagye +7 more
TL;DR: The design, synthesis and initial characterisation of the first pyrimidoindolone compound for detection of caspase-3/7 activation using positron emission tomography is described.
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Regiochemical observations on the lithiation of 1,2,4-trichlorobenzene and reaction with DMF and oxamide electrophiles in THF
Andrew J. Burton,Kevin S. Cardwell,Matthew J. Fuchter,Mika Kristian Lindvall,Rajnikant Patel,Terry W. Packham,Jeremy C. Prodger,Mark B. Schilling,Matthew D. Walker +8 more
TL;DR: In this paper, the reaction of 1,2,4-trichlorobenzene with N,N-dimethylformamide and tetraalkyloxamides was studied.
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Thermodynamics of ligand binding to histone deacetylase like amidohydrolase from Bordetella/Alcaligenes.
Christian Meyners,Matthias G. J. Baud,Matthias G. J. Baud,Matthew J. Fuchter,Franz-Josef Meyer-Almes +4 more
TL;DR: A novel sensitive competitive fluorescence resonance energy transfer‐based binding assay was developed and the thermodynamics of interaction of both fluorescent ligands and inhibitors to histone deacetylase like amidohydrolase were investigated, highlighting the importance of thermodynamic signatures for the optimization of ligands or rational drug design.
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Effective macrophage delivery using RAFT copolymer derived nanoparticles
Katherine Montgomery,Katherine Montgomery,Robert W. M. Davidson,Benjamin Cao,Benjamin Cao,Brenda Williams,Brenda Williams,G. W. Simpson,Susan K. Nilsson,Susan K. Nilsson,John Chiefari,Matthew J. Fuchter +11 more
TL;DR: The nanoparticles’ stability at increased temperatures and at low concentrations, the tunability of their synthesis and their extensive internalisation by macrophages and performance makes them highly promising delivery vehicles for a range of therapeutics and imaging agents.
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Computational Screening of Chiral Organic Semiconductors: Exploring Side-Group Functionalization and Assembly to Optimize Charge Transport
Julia A. Schmidt,Joseph A. Weatherby,Isaac J. Sugden,Alejandro Santana-Bonilla,Francesco Salerno,Matthew J. Fuchter,Erin R. Johnson,Jenny Nelson,Kim E. Jelfs +8 more