M
Matthew J. Fuchter
Researcher at Imperial College London
Publications - 159
Citations - 6834
Matthew J. Fuchter is an academic researcher from Imperial College London. The author has contributed to research in topics: Chemistry & Medicine. The author has an hindex of 36, co-authored 134 publications receiving 4871 citations. Previous affiliations of Matthew J. Fuchter include Emory University & University of London.
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Journal ArticleDOI
Arylazopyrazoles: Azoheteroarene Photoswitches Offering Quantitative Isomerization and Long Thermal Half-Lives
Claire E. Weston,Robert D. Richardson,Peter R. Haycock,Andrew J. P. White,Matthew J. Fuchter +4 more
TL;DR: The conformation of the Z isomers of these compounds, and also the arylazopyrroles, is highly dependent on the substitution pattern on the heteroarene, allowing a twisted or planar geometry, which in turn has a significant impact on the electronic spectral properties of the compounds.
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Nonmetal Catalyzed Hydrogenation of Carbonyl Compounds
TL;DR: Solutions of the Lewis acid B(C6F5)3 in 1,4-dioxane are found to effectively catalyze the hydrogenation of a variety of ketones and aldehydes through a "frustrated Lewis pair" mechanism in which the solvent plays a pivotal role.
Journal ArticleDOI
Tuning azoheteroarene photoswitch performance through heteroaryl design
Joaquín Calbo,Claire E. Weston,Andrew J. P. White,Henry Rzepa,Julia Contreras-García,Matthew J. Fuchter +5 more
TL;DR: A systematic computational and experimental study is presented to elucidate the origin of the long thermal half-lives and excellent addressability of the arylazopyrazoles, and apply this understanding to determine important structure-property relationships for a wide array of comparable azoheteroaryl photoswitches.
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Persistence and activation of malaria hypnozoites in long-term primary hepatocyte cultures
Laurent Dembele,Jean-François Franetich,Audrey Lorthiois,Audrey Gego,Anne-Marie Zeeman,Clemens H. M. Kocken,Roger Le Grand,Nathalie Dereuddre-Bosquet,Geert-Jan van Gemert,Robert W. Sauerwein,Jean-Christophe Vaillant,Laurent Hannoun,Matthew J. Fuchter,Thierry T. Diagana,Nicholas A. Malmquist,Artur Scherf,Georges Snounou,Dominique Mazier +17 more
TL;DR: Evidence is obtained that exposure to an inhibitor of histone modification enzymes implicated in epigenetic control of gene expression induces an accelerated rate of hypnozoite activation, and may enable investigations of hyp nozoite biology and the search for compounds that killhypnozoites or disrupt their quiescence.
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Designing effective ‘frustrated Lewis pair’ hydrogenation catalysts
TL;DR: This tutorial review aims to provide a focused guide to the development of efficient FLP hydrogenation catalysts, through identification and consideration of the key factors that govern their effectiveness.