M
Matthew J. Fuchter
Researcher at Imperial College London
Publications - 159
Citations - 6834
Matthew J. Fuchter is an academic researcher from Imperial College London. The author has contributed to research in topics: Chemistry & Medicine. The author has an hindex of 36, co-authored 134 publications receiving 4871 citations. Previous affiliations of Matthew J. Fuchter include Emory University & University of London.
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Journal ArticleDOI
Dual EZH2 and EHMT2 histone methyltransferase inhibition increases biological efficacy in breast cancer cells
Edward Curry,Ian Green,Nadine Chapman-Rothe,Elham Shamsaei,Sarah Kandil,Fanny L. Cherblanc,Luke Payne,Emma Bell,Thota Ganesh,Nitipol Srimongkolpithak,Joachim Caron,Fengling Li,Anthony G. Uren,James P. Snyder,Masoud Vedadi,Matthew J. Fuchter,Robert S. Brown +16 more
TL;DR: It is demonstrated that dual inhibition of EZH2 and EHMT2 is more effective at eliciting biological responses of gene transcription and cancer cell growth inhibition compared to inhibition of single HKMTs, and the first dual EZh2-EHMT1/2 substrate competitive inhibitors that are functional in cells are reported.
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A scalable and expedient route to 1-aza[6]helicene derivatives and its subsequent application to a chiral-relay asymmetric strategy.
TL;DR: A rapid route to diversely functionalized 1-aza[6]helicenes has been achieved via the development of a copper-mediated cross-coupling reaction, followed by PtCl4-catalyzed cycloisomerization, suitable for relaying the axial chirality of a key intermediate to the helicity of the product.
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Natural optical activity as the origin of the large chiroptical properties in π-conjugated polymer thin films.
Jessica Wade,James N. Hilfiker,Jochen R. Brandt,Letizia Liirò-Peluso,Li Wan,Xingyuan Shi,Francesco Salerno,Seán T. J. Ryan,S. Schöche,Oriol Arteaga,Tamás Jávorfi,Giuliano Siligardi,Cheng Wang,David B. Amabilino,Peter H. Beton,Alasdair J. Campbell,Matthew J. Fuchter +16 more
TL;DR: It is shown that – under conditions relevant for device fabrication – the large chiroptical effects are caused by magneto-electric coupling, not structural chirality as previously assumed, and may occur because of local order in a cylinder blue phase-type organisation.
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Ring-Opening Metathesis Polymer Sphere-Supported seco-Porphyrazines: Efficient and Recyclable Photooxygenation Catalysts
TL;DR: Polymerization gave the corresponding ROMPgel and ROMPsphere reagents, the latter of which proved efficient as an immobilized catalyst for the sensitized production of singlet oxygen for the purification-minimized parallel synthesis of endoperoxides and ene adducts.
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[7]-Helicene: a chiral molecular tweezer for silver(I) salts
Matthew J. Fuchter,Julia Schaefer,Dilraj K. Judge,Benjamin Wardzinski,Marko Weimar,Ingo Krossing +5 more
TL;DR: It is unambiguously demonstrated the binding of the silver(I) ion in the central cavity of [7]-helicene, given that the counterion is weakly coordinating.