Q
Quang-Dé Nguyen
Researcher at Harvard University
Publications - 82
Citations - 5179
Quang-Dé Nguyen is an academic researcher from Harvard University. The author has contributed to research in topics: Cancer & Kinase. The author has an hindex of 34, co-authored 80 publications receiving 3827 citations. Previous affiliations of Quang-Dé Nguyen include Brigham and Women's Hospital & Imperial College London.
Papers
More filters
Journal ArticleDOI
An Integrative Model of Cellular States, Plasticity, and Genetics for Glioblastoma
Cyril Neftel,Julie Laffy,Mariella G. Filbin,Toshiro Hara,Marni E. Shore,Marni E. Shore,Gilbert J. Rahme,Gilbert J. Rahme,Alyssa R. Richman,Alyssa R. Richman,Dana Silverbush,Dana Silverbush,McKenzie Shaw,Christine M. Hebert,Christine M. Hebert,John M. DeWitt,John M. DeWitt,Simon Gritsch,Simon Gritsch,Elizabeth M. Perez,Elizabeth M. Perez,L. Nicolas Gonzalez Castro,Xiaoyang Lan,Xiaoyang Lan,Nicholas Druck,Christopher Rodman,Danielle Dionne,Alexander Kaplan,Mia Bertalan,Julia L. Small,Kristine Pelton,Sarah Becker,Dennis M. Bonal,Quang-Dé Nguyen,Rachel L. Servis,Jeremy M. Fung,Ravindra Mylvaganam,Lisa Mayr,Johannes Gojo,Christine Haberler,René Geyeregger,Thomas Czech,Irene Slavc,Brian V. Nahed,William T. Curry,Bob S. Carter,Hiroaki Wakimoto,Priscilla K. Brastianos,Tracy T. Batchelor,Anat Stemmer-Rachamimov,Maria Martinez-Lage,Matthew P. Frosch,Ivan Stamenkovic,Nicolo Riggi,Esther Rheinbay,Esther Rheinbay,Michelle Monje,Orit Rozenblatt-Rosen,Daniel P. Cahill,Anoop P. Patel,Tony Hunter,Inder M. Verma,Keith L. Ligon,Keith L. Ligon,David N. Louis,Aviv Regev,Aviv Regev,Bradley E. Bernstein,Bradley E. Bernstein,Itay Tirosh,Mario L. Suvà,Mario L. Suvà +71 more
TL;DR: It is found that malignant cells in glioblastoma exist in four main cellular states that recapitulate distinct neural cell types, are influenced by the tumor microenvironment, and exhibit plasticity.
Journal ArticleDOI
Developmental and oncogenic programs in H3K27M gliomas dissected by single-cell RNA-seq
Mariella G. Filbin,Itay Tirosh,Itay Tirosh,Volker Hovestadt,Volker Hovestadt,McKenzie Shaw,McKenzie Shaw,Leah E. Escalante,Leah E. Escalante,Nathan Mathewson,Cyril Neftel,Nelli Frank,Kristine Pelton,Christine M. Hebert,Christine M. Hebert,Christine Haberler,Keren Yizhak,Johannes Gojo,Kristof Egervari,Christopher Mount,Peter van Galen,Peter van Galen,Dennis M. Bonal,Quang-Dé Nguyen,Alexander M. Beck,Claire Sinai,Claire Sinai,Thomas Czech,Christian Dorfer,Liliana Goumnerova,Cinzia Lavarino,Angel M. Carcaboso,Jaume Mora,Ravindra Mylvaganam,Christina C. Luo,Andreas Peyrl,Mara Popović,Amedeo A. Azizi,Tracy T. Batchelor,Matthew P. Frosch,Maria Martinez-Lage,Mark W. Kieran,Pratiti Bandopadhayay,Pratiti Bandopadhayay,Rameen Beroukhim,Rameen Beroukhim,Gerhard Fritsch,Gad Getz,Gad Getz,Orit Rozenblatt-Rosen,Kai W. Wucherpfennig,David N. Louis,Michelle Monje,Irene Slavc,Keith L. Ligon,Keith L. Ligon,Keith L. Ligon,Todd R. Golub,Todd R. Golub,Aviv Regev,Aviv Regev,Bradley E. Bernstein,Bradley E. Bernstein,Mario L. Suvà,Mario L. Suvà +64 more
TL;DR: This study characterizes oncogenic and developmental programs in H3K27M-glioma at single-cell resolution and across genetic subclones, suggesting potential therapeutic targets in this disease.
Journal ArticleDOI
Tenascin-C and SF/HGF produced by myofibroblasts in vitro provide convergent pro-invasive signals to human colon cancer cells through RhoA and Rac.
Olivier De Wever,Quang-Dé Nguyen,Leen Van Hoorde,Marc Bracke,Erik Bruyneel,Christian Gespach,Marc Mareel +6 more
TL;DR: In vitro results point to a new putative proinvasive signal for colon cancer cells provided by myofibroblasts in the tumor stroma.
Journal ArticleDOI
Nuclear bodies and compartments: functional roles and cellular signalling in health and disease.
TL;DR: Some aspects of nuclear structures/bodies/domains are summarized, including their proposed roles in cellular signalling and in human diseases, mainly neurodegenerative disorders and cancer.
Journal ArticleDOI
Positron emission tomography imaging of drug-induced tumor apoptosis with a caspase-3/7 specific [18F]-labeled isatin sulfonamide.
TL;DR: It is demonstrated that [18F]ICMT-11 binds to a range of drug-induced apoptotic cancer cells in vitro and to 38C13 murine lymphoma xenografts in vivo by up to 2-fold at 24 h posttreatment compared to vehicle treatment.