M
Matthew Neal
Researcher at Northeast Ohio Medical University
Publications - 19
Citations - 1104
Matthew Neal is an academic researcher from Northeast Ohio Medical University. The author has contributed to research in topics: Neuroinflammation & Neurodegeneration. The author has an hindex of 13, co-authored 17 publications receiving 730 citations. Previous affiliations of Matthew Neal include Iowa State University & Florida International University.
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Journal ArticleDOI
Fyn kinase regulates misfolded α-synuclein uptake and NLRP3 inflammasome activation in microglia.
Nikhil Panicker,Nikhil Panicker,Souvarish Sarkar,Dilshan S. Harischandra,Matthew Neal,Tae In Kam,Huajun Jin,Hariharan Saminathan,Monica R. Langley,Adhithiya Charli,Manikandan Samidurai,Dharmin Rokad,Shivani Ghaisas,Olga Pletnikova,Valina L. Dawson,Ted M. Dawson,Vellareddy Anantharam,Anumantha G. Kanthasamy,Arthi Kanthasamy +18 more
TL;DR: Fyn kinase mediates aggregated α-synuclein uptake as well as αSyn-mediated proinflammatory signaling in microglia, leading to NLRP3 inflammasome activation and neuroinflammation in Parkinson’s disease.
Journal ArticleDOI
Fyn Kinase Regulates Microglial Neuroinflammatory Responses in Cell Culture and Animal Models of Parkinson's Disease
Nikhil Panicker,Hariharan Saminathan,Huajun Jin,Matthew Neal,Dilshan S. Harischandra,Richard D. Gordon,Kavin Kanthasamy,Vivek Lawana,Souvarish Sarkar,Jie Luo,Vellareddy Anantharam,Anumantha G. Kanthasamy,Arthi Kanthasamy +12 more
TL;DR: In this paper, the role of Fyn, a non-receptor tyrosine kinase, in microglial activation and neuroinflammatory mechanisms in cell culture and animal models of Parkinson's disease was examined.
Journal ArticleDOI
Epigenetic regulation of astrocyte function in neuroinflammation and neurodegeneration.
Matthew Neal,Jason R. Richardson +1 more
TL;DR: This review examines the known epigenetic mechanisms involved in regulation of astrocyte function, from development to neurodegeneration, and links these mechanisms to potential astroCyte-specific roles in neurodegnerative disease with a focus on potential opportunities for therapeutic intervention.
Journal ArticleDOI
Manganese promotes the aggregation and prion-like cell-to-cell exosomal transmission of α-synuclein
Dilshan S. Harischandra,Dharmin Rokad,Matthew Neal,Shivani Ghaisas,Sireesha Manne,Souvarish Sarkar,Nikhil Panicker,Gary Zenitsky,Huajun Jin,Mechelle M. Lewis,Xuemei Huang,Vellareddy Anantharam,Arthi Kanthasamy,Anumantha G. Kanthasamy +13 more
TL;DR: Results indicate that Mn2+ exposure promotes αSyn secretion in exosomal vesicles, which subsequently evokes proinflammatory and neurodegenerative responses in both cell culture and animal models.
Journal ArticleDOI
A Simple Magnetic Separation Method for High-Yield Isolation of Pure Primary Microglia
Richard D. Gordon,Colleen Hogan,Matthew Neal,Vellareddy Anantharam,Anumantha G. Kanthasamy,Arthi Kanthasamy +5 more
TL;DR: A novel column-free magnetic separation protocol for high-yield isolation of primary microglia from mouse postnatal mixed glial cultures is described, which yields microglial cells that are fully functional and respond like cells obtained by conventional isolation techniques.