Matthew R. G. Russell

TL;DR: Depletion of tumour susceptibility gene 101 impairs the selection of epidermal growth factor receptor away from recycling receptors within the limiting membrane of the early endosome, resulting in inhibition of cargo recycling and profound structural rearrangement of theEarly Endosome.

TL;DR: Bedaquiline accumulated primarily in host cell lipid droplets, but heterogeneously in mycobacteria within a variety of intracellular compartments, which constituted a transferable reservoir that enhanced antibacterial efficacy.

TL;DR: Current evidence supports a model of maturation in which the lipids, cargo proteins and Rab population at the endosome determine its competence to perform the functions of late endosomes, including the sorting of cargoes into lumenal vesicles and fusion with lysosomes.

TL;DR: The workflow revealed new insight into the replicative niche of Mycobacterium tuberculosis in primary human lymphatic endothelial cells, HIV-1 in human monocyte-derived macrophages, and the composition of the entotic vacuole.

TL;DR: After infection, a population of macrophages became necrotic, providing a niche for M. tuberculosis replication before escaping into the extracellular milieu, and it is discovered that IFN-&ggr; enhanced bacterial replication in macrophage colony-stimulating factor–differentiated Macrophages more than in granulocyte–macrophage Colony-stimulation factor– differentiated macrophaging.