M
Matthew Ryals
Researcher at University of Virginia
Publications - 8
Citations - 200
Matthew Ryals is an academic researcher from University of Virginia. The author has contributed to research in topics: Drug repositioning & Adenosine A1 receptor. The author has an hindex of 5, co-authored 7 publications receiving 173 citations. Previous affiliations of Matthew Ryals include University of California, San Diego.
Papers
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Journal ArticleDOI
Sound preconditioning therapy inhibits ototoxic hearing loss in mice
TL;DR: A sound exposure protocol that induces HSPs in the cochlea and inhibit ototoxic drug–induced hearing loss is developed and it is suggested that sound therapy holds promise for preventing hearing loss in patients receiving these drugs.
Journal ArticleDOI
Characterization of spontaneous, transient adenosine release in the caudate-putamen and prefrontal cortex.
Michael D. Nguyen,Scott T. Lee,Ashley E. Ross,Matthew Ryals,Vishesh I. Choudhry,B. Jill Venton +5 more
TL;DR: Spontaneous, transient adenosine release in vivo, in the caudate-putamen and prefrontal cortex of anesthetized rats is characterized, demonstrating that there is a rapid mode ofAdenosine signaling that could cause transient, local neuromodulation.
Journal ArticleDOI
Drug repositioning in SLE: crowd-sourcing, literature-mining and Big Data analysis.
Amrie C. Grammer,Matthew Ryals,Sarah E Heuer,Rob D Robl,Sushma Madamanchi,Laurie S. Davis,Bernard Lauwerys,Michelle D. Catalina,Peter E. Lipsky +8 more
TL;DR: The usefulness of a multi-pronged approach to drug repositioning in lupus is highlighted by orthogonal confirmation of hypothesis-based drug reppositioning predictions by “Big Data” analysis of differentially expressed genes from l upus patient samples.
Journal ArticleDOI
Clearance of rapid adenosine release is regulated by nucleoside transporters and metabolism.
TL;DR: The presence of multiple mechanisms forAdenosine clearance on a time scale of seconds demonstrates that adenosine is tightly regulated in the extracellular space.
Journal ArticleDOI
A kinase inhibitor library screen identifies novel enzymes involved in ototoxic damage to the murine organ of Corti
TL;DR: Of the 160 kinase inhibitors screened, 15 exhibited a statistically significant protective effect, while 3 significantly enhanced HC loss, and several novel potential kinase pathway contributions to ototoxicity are highlighted.