Matthew Wright

TL;DR: An efficient sequencing approach with hydrogel-tissue chemistry was combined to develop a multidisciplinary technology for three-dimensional (3D) intact-tissues RNA sequencing and widespread up-regulation of activity-regulated genes was observed in response to visual stimulation.

TL;DR: Evidence is presented that oxytocin (OXT) release in the ventral tegmental area (VTA), a key node of the brain’s reward circuitry, is necessary to elicit social reward and promotes prosocial behavior through direct effects on VTA DA neurons, thus providing mechanistic insight into how social interactions can generate rewarding experiences.

TL;DR: The hippocampus encodes not only neutral but also valence-related contextual information, and the vCA1-LHA pathway is a direct route by which the hippocampus can rapidly influence innate anxiety behavior.

TL;DR: Real-time modulation of E:I balance in the mouse prefrontal cortex can rescue social behavior deficits reminiscent of autism phenotypes, and highlights the potential for modulating neural circuits in the brain as a strategy for treating autism.

TL;DR: The marine cyanobacterium Prochlorococcus MED4 has the smallest genome and cell size of all known photosynthetic organisms, and its transitions between photosynthesis during the day and catabolic consumption of energy reserves at night appear to be tightly choreographed at the level of RNA expression.