Robert G. Steen

TL;DR: The final report of the concerted effort to produce a dense genetic map of the laboratory mouse contains 7,377 genetic markers, consisting of 6,580 highly informative simple sequence length polymorphisms integrated with 797 restriction fragmentlength polymorphisms in mouse genes.

TL;DR: Inactivation of the murine Dcc gene caused defects in axonal projections that are similar to those observed in netrin-1-deficient mice but did not affect growth, differentiation, morphogenesis or tumorigenesis in mouse intestine, which is consistent with the hypothesis that DCC is a component of a receptor for netrin -1.

TL;DR: Admixture mapping indicates a major, still-unidentified risk gene for prostate cancer at 8q24, motivating intense work to find it and finding that the previously described alleles do not explain more than a fraction of the admixture signal.

TL;DR: This map represents the two–thirds point toward the goal of developing a mouse genetic map containing 6,000 SSLPs, and there is a significant underrepresentation of markers on the X chromosome.

TL;DR: This work presents a new generation of high-resolution genetic linkage maps for the mouse that offer exciting prospects for understanding mammalian genome evolution through comparative mapping, for developing mouse models of human disease, and for identifying the function of all genes in the organism.