Matthias Bros

TL;DR: Improvements in DNA vaccine design include the use of APC-specific promotors for transcriptional targeting, the arrangement of multiple antigen sequences, the co-delivery of molecular adjuvants to prevent tolerance induction, and strategies to circumvent potential inhibitory effects of the vector backbone.

TL;DR: Current knowledge about parameters of regulation of IL-1β expression and its multi-facetted role in pathophysiological conditions are summarized and it is indicated that IL- 1β is a driver of tumor induction and development.

TL;DR: Phosphorylated osteopontin, a protein involved in bone re absorption and in immune regulation, accumulates in serum, urine and cells cultured from TRAP-deficient individuals and case-derived dendritic cells exhibit an altered cytokine profile and are more potent than matched control cells in stimulating allogeneic T cell proliferation in mixed lymphocyte reactions.

TL;DR: The polypeptoid-block-polypeptide formulation increased solubility of the drug and enhances its bioavailability, which leads to a reduction of intracellular cAMP levels in MaMel 91 melanoma cells.

TL;DR: This review aims to summarize the current knowledge on the role of RhoA as a general key regulator of immune cell differentiation and function in T cells and B cells as the effector cells of the adaptive immune system.