Matthias Bureik

TL;DR: It was found that overexpression of this gene significantly enhances steroid hydroxylase activity of CYP11B2 expressing fission yeast cells, and a gene was identified that codes for a protein with an amino terminal domain homologous to COX15 of Saccharomyces cerevisiae and a carboxy terminal ferredoxin domain to be named etp1 (electron-transfer protein 1).

TL;DR: A potent and rather selective non-steroidal inhibitor of human CYP11B2 was detected with an IC(50) value of 59nM and a very potent inhibitor of both enzymes showing a stronger inhibitory activity against the cortisol producing CYP 11B1 was identified.

TL;DR: The pharmacological and toxicological importance of these steroid hydroxylases, the means for the identification of their potential inhibitors and possible biotechnological applications are discussed.

TL;DR: The findings show that glioblastoma multiforme cell lines metabolize calcidiol and the effect of vitamin D3 metabolites on proliferation, and various effects mediated by calcitriol are shown.

TL;DR: This study proposed aldosterone synthase (CYP11B2) as a novel target for the treatment of congestive heart failure and myocardial fibrosis and the synthesis and biological evaluation of substituted E- and Z-imidazolylmethylenetetrahydronaphthalenes and E-