M
Matthias Oelze
Researcher at University of Mainz
Publications - 79
Citations - 4670
Matthias Oelze is an academic researcher from University of Mainz. The author has contributed to research in topics: Oxidative stress & Endothelial dysfunction. The author has an hindex of 36, co-authored 79 publications receiving 3760 citations.
Papers
More filters
Journal ArticleDOI
Vascular Inflammation and Oxidative Stress: Major Triggers for Cardiovascular Disease
Sebastian Steven,Katie Frenis,Matthias Oelze,Sanela Kalinovic,Marin Kuntic,Maria Teresa Bayo Jimenez,Ksenija Vujacic-Mirski,Johanna Helmstädter,Swenja Kröller-Schön,Thomas Münzel,Andreas Daiber +10 more
TL;DR: The value of immunomodulation for the treatment of cardiovascular disease was recently supported by large-scale clinical trials demonstrating reduced cardiovascular mortality in patients with established atherosclerotic disease when treated by highly specific anti-inflammatory therapies.
Journal ArticleDOI
The sodium-glucose co-transporter 2 inhibitor empagliflozin improves diabetes-induced vascular dysfunction in the streptozotocin diabetes rat model by interfering with oxidative stress and glucotoxicity.
Matthias Oelze,Swenja Kröller-Schön,Philipp Welschof,Thomas Jansen,Michael Hausding,Yuliya Mikhed,Paul Stamm,Michael Mader,Elena Zinßius,Saule Agdauletova,Anna Gottschlich,Sebastian Steven,Eberhard Schulz,Serge P. Bottari,Eric Mayoux,Thomas Münzel,Andreas Daiber +16 more
TL;DR: Empagliflozin improves hyperglycemia and prevents the development of endothelial dysfunction, reduces oxidative stress and improves the metabolic situation in type 1 diabetic rats.
Journal ArticleDOI
Manganese superoxide dismutase and aldehyde dehydrogenase deficiency increase mitochondrial oxidative stress and aggravate age-dependent vascular dysfunction
Philip Wenzel,Swenja Schuhmacher,Joachim Kienhöfer,Johanna Müller,Marcus Hortmann,Matthias Oelze,Eberhard Schulz,Nicolai Treiber,Toshihiro Kawamoto,Karin Scharffetter-Kochanek,Thomas Münzel,Alexander Bürkle,Markus Bachschmid,Andreas Daiber +13 more
TL;DR: The correlation between mtROS formation and acetylcholine-dependent relaxation revealed that mitochondrial radical formation significantly contributes to age-dependent endothelial dysfunction.
Journal ArticleDOI
Crosstalk of mitochondria with NADPH oxidase via reactive oxygen and nitrogen species signalling and its role for vascular function.
Andreas Daiber,Fabio Di Lisa,Matthias Oelze,Swenja Kröller-Schön,Sebastian Steven,Eberhard Schulz,Thomas Münzel +6 more
TL;DR: The general concept of redox‐based activation of RONS sources via “kindling radicals” and enzyme‐specific “redox switches” will be discussed providing evidence that mitochondria represent key players and amplifiers of the burden of oxidative stress.
Journal ArticleDOI
The SGLT2 inhibitor empagliflozin improves the primary diabetic complications in ZDF rats.
Sebastian Steven,Matthias Oelze,Alina Hanf,Swenja Kröller-Schön,Fatemeh Kashani,Siyer Roohani,Philipp Welschof,Maximilian Kopp,Ute Gödtel-Armbrust,Ning Xia,Huige Li,Eberhard Schulz,Karl J. Lackner,Leszek Wojnowski,Serge P. Bottari,Philip Wenzel,Eric Mayoux,Thomas Münzel,Andreas Daiber,Andreas Daiber +19 more
TL;DR: Empagliflozin reduces glucotoxicity and thereby prevents the development of endothelial dysfunction, reduces oxidative stress and exhibits anti-inflammatory effects in ZDF rats, despite persisting hyperlipidemia and hyperinsulinemia.