T
Thomas Vogt
Researcher at Saarland University
Publications - 160
Citations - 2999
Thomas Vogt is an academic researcher from Saarland University. The author has contributed to research in topics: Vitamin D and neurology & Melanoma. The author has an hindex of 22, co-authored 159 publications receiving 2495 citations. Previous affiliations of Thomas Vogt include University Hospital Regensburg.
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Journal ArticleDOI
Overcoming Intrinsic Multidrug Resistance in Melanoma by Blocking the Mitochondrial Respiratory Chain of Slow-Cycling JARID1Bhigh Cells
Alexander Roesch,Adina Vultur,Ivan Bogeski,Huan Wang,Katharina M. Zimmermann,David W. Speicher,Christina Körbel,Matthias W. Laschke,Phyllis A. Gimotty,Stephan E. Philipp,Elmar Krause,Sylvie Pätzold,Jessie Villanueva,Clemens Krepler,Mizuho Fukunaga-Kalabis,Markus Hoth,Boris C. Bastian,Thomas Vogt,Meenhard Herlyn +18 more
TL;DR: These findings support a two-tiered approach combining anticancer agents that eliminate rapidly proliferating melanoma cells with inhibitors of the drug-resistant slow-cycling subpopulation, and support an intrinsic multidrug resistance based on the survival of a tumor cell subpopulation.
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Complete lymph node dissection versus no dissection in patients with sentinel lymph node biopsy positive melanoma (DeCOG-SLT): a multicentre, randomised, phase 3 trial
Ulrike Leiter,Rudolf Stadler,Cornelia Mauch,Werner Hohenberger,Norbert H. Brockmeyer,Carola Berking,Cord Sunderkötter,Martin Kaatz,Klaus-Werner Schulte,Percy Lehmann,Thomas Vogt,Jens Ulrich,Rudolf A. Herbst,Wolfgang Gehring,Jan-Christoph Simon,Ulrike Keim,Peter Martus,Claus Garbe +17 more
TL;DR: Results showed no difference in survival in patients treated with complete lymph node dissection compared with observation only, and complete lymph nodes dissection should not be recommended in patients with melanoma with lymph node micrometastases of at least a diameter of 1 mm or smaller.
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Induction of Hsp90 protein expression in malignant melanomas and melanoma metastases
Bernd Becker,Gabriele Multhoff,Beatrix Farkas,Peter J. Wild,Michael Landthaler,Wilhelm Stolz,Thomas Vogt +6 more
TL;DR: It is concluded that Hsp90 is present in advanced malignant melanomas and may have a stabilizing effect on the cellular functions in proliferating cells of melanocytic lesions and could thereby be a prerequisite for the tumor progression.
Journal ArticleDOI
Quantification of nanoparticle uptake into hair follicles in pig ear and human forearm
Anne S. Raber,Ankit Mittal,Jens Schäfer,Udo Bakowsky,J. Reichrath,Thomas Vogt,Ulrich F. Schaefer,Steffi Hansen,Claus-Michael Lehr +8 more
TL;DR: The suitability of the pig ear model as a surrogate for the in vivo situation in humans for quantifying NP uptake into HF is supported, and the findings may help to optimize NP for targeting the HF and to improve transdermal delivery.
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Same Site Recurrence is More Frequent After Endovenous Laser Ablation Compared with High Ligation and Stripping of the Great Saphenous Vein: 5 year Results of a Randomized Clinical Trial (RELACS Study)
TL;DR: Evaluated treatments of endovenous laser ablation with high ligation and stripping as standard treatment for great saphenous vein incompetence and HLS are comparably effective concerning overall REVAS, improvement of disease severity, and quality of life.