A
A.-M. Camus
Researcher at International Agency for Research on Cancer
Publications - 39
Citations - 1889
A.-M. Camus is an academic researcher from International Agency for Research on Cancer. The author has contributed to research in topics: Carcinogen & Lung cancer. The author has an hindex of 24, co-authored 39 publications receiving 1865 citations. Previous affiliations of A.-M. Camus include German Cancer Research Center.
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Journal ArticleDOI
Validation and comparative studies on 180 chemicals with S. typhimurium strains and V79 Chinese hamster cells in the presence of various metabolizing systems.
Helmut Bartsch,Christian Malaveille,A.-M. Camus,Ghyslaine Martel-Planche,G. Brun,Agnès Hautefeuille,N. Sabadie,Alain Barbin,T. Kuroki,C. Drevon,C. Piccoli,Ruggero Montesano +11 more
TL;DR: The predictive value of the test, the quantitative relationship between mutagenicity versus electrophilicity versus carcinogenicity of some selected carcinogens, and some factors involved in the efficient detection of mutagens in vitro were analyzed.
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Expression and polymorphism of glutathione S-transferase in human lungs: risk factors in smoking-related lung cancer
Tamie Nakajima,Eivor Elovaara,Sisko Anttila,Ari Hirvonen,A.-M. Camus,John D. Hayes,Brian Ketterer,Harri Vainio +7 more
TL;DR: The data support the idea that in smokers who lack the GSTM1 gene, activation of carcinogens in tobacco smoke is increased, while the efficacy of detoxification is limited both qualitatively (absence of GSTm1-1 enzyme and low expression of GSTM3-3 enzyme) and quantitatively (low overall GST activity).
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Mutagenicity of vinyl chloride, chloroethyleneoxide, chloroacetaldehyde and chloroethanol.
Christian Malaveille,Helmut Bartsch,Alain Barbin,A.-M. Camus,Ruggero Montesano,Alain Croisy,P. Jacquignon +6 more
TL;DR: Exposure of S. typhimurium strains TA 1530, TA 1535 and G-46 to vinyl chloride increased the number of his+ rev./plate 16, 12 or 5 times over the spontaneous mutation rate.
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High variability of nitrosamine metabolism among individuals: Role of cytochromes P450 2A6 and 2E1 in the dealkylation of N-nitrosodimethylamine and N-nitrosodiethylamine in mice and humans
A.-M. Camus,Olivier Geneste,Paavo Honkakoski,Jean-Claude Béréziat,Colin J. Henderson,Roland Wolf,Helmut Bartsch,Matti A. Lang +7 more
TL;DR: The data suggest that the metabolic activation of nitrosamines in humans varies greatly among individuals; (2) different nitrosamine may partially be metabolized by different cytochrome P450 isozymes; and (3) inbred strains of mice would be relevant experimental models for studyingNitrosamine activation.
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Smoking and peripheral type of cancer are related to high levels of pulmonary cytochrome P450IA in lung cancer patients.
Sisko Anttila,Eino Hietanen,Hard Vainio,A.-M. Camus,Harry V. Gelboin,Sang S. Park,Lasse Heikkilä,Antti Karjalainen,Helmut Bartsch,Helmut Bartsch +9 more
TL;DR: The data suggest that the smokers who have an inducible cytochrome P450IA are especially at increased risk of developing lung cancer of the peripheral adenocarcinomatous type.