Mauricio Tohen

TL;DR: The first double-blind placebo-controlled clinical trial of an atypical neuroleptic medication is being conducted in symptomatic treatment-seeking patients meeting new diagnostic criteria for a putative prodromal syndrome, identifying them as being at high risk for developing psychosis in the near future.

TL;DR: Suicidal behavior was strongly associated with prior suicide attempts, more time depressed, and younger age or recent onset and lithium maintenance was associated with marked reduction of life-threatening suicidal acts, the number of which sharply increased after discontinuing lithium.

TL;DR: Comorbidity is common and may be a useful predictor of the outcome of a first episode of psychosis, while those with medical comorbidities had fewer symptoms at discharge.

TL;DR: Factor analyses of the PANSS consistently uncovered an excitement factor including uncooperativeness, poor impulse control, excitement, and hostility items that may be useful in examining manic symptoms in studies where the addition of a scale specific to mania would be burdensome and where symptoms of excitement are part of the clinical presentation.

TL;DR: Syndromal recovery was achieved by nearly one half of patients within 3 months of a first lifetime hospitalization for a psychotic illness, but functional recovery was not achieved by 6 months in nearly two thirds of patients who had attained syndromal Recovery.