M
Mauro Cortez
Researcher at University of São Paulo
Publications - 38
Citations - 1237
Mauro Cortez is an academic researcher from University of São Paulo. The author has contributed to research in topics: Trypanosoma cruzi & Leishmania. The author has an hindex of 18, co-authored 36 publications receiving 1060 citations. Previous affiliations of Mauro Cortez include University of Maryland, College Park & University of Antofagasta.
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Journal ArticleDOI
Trypanosoma cruzi subverts the sphingomyelinase-mediated plasma membrane repair pathway for cell invasion
Maria Cecilia Fernandes,Mauro Cortez,Andrew R. Flannery,Christina Tam,Renato A. Mortara,Norma W. Andrews +5 more
TL;DR: It is shown that host cell entry by T. cruzi mimics a process of plasma membrane injury and repair that involves Ca(2+)-dependent exocytosis of lysosomes, delivery of acid sphingomyelinase to the outer leaflet of the plasma membrane, and a rapid form of endocytoses that internalizes membrane lesions.
Journal ArticleDOI
Caveolae internalization repairs wounded cells and muscle fibers.
Matthias Corrotte,Patrícia E. Almeida,Patrícia E. Almeida,Christina Tam,Thiago Castro-Gomes,Maria Cecilia Fernandes,Bryan A. Millis,Mauro Cortez,Heather Miller,Wenxia Song,Timothy K. Maugel,Norma W. Andrews +11 more
TL;DR: This work shows that muscle fibers and other cell types repair membrane wounds by a mechanism involving Ca2+-triggered exocytosis of lysosomes, release of acid sphingomyelinase, and rapid lesion removal by caveolar endocyTosis, providing a mechanistic explanation for the muscle pathology associated with mutations in caveolae proteins.
Journal ArticleDOI
Iron uptake controls the generation of Leishmania infective forms through regulation of ROS levels
Bidyottam Mittra,Mauro Cortez,Andrew Haydock,Gowthaman Ramasamy,Peter J. Myler,Peter J. Myler,Norma W. Andrews +6 more
TL;DR: Iron uptake promotes hydrogen peroxide–dependent differentiation of Leishmania promastigote into infective amastigotes into infectives amastsigotes.
Book ChapterDOI
Trypanosoma cruzi: Parasite and Host Cell Signaling during the Invasion Process
Nobuko Yoshida,Mauro Cortez +1 more
TL;DR: The mechanisms of host cell invasion by T. cruzi have been partially elucidated and surface molecules that bind to host cells as a prelude to invasion appear to be devoid of signaling properties, but they may induce TCT enzymes, such as oligopeptidase B and cruzipain, to generate Ca2+ signaling factors of parasite or host cell origin.
Journal ArticleDOI
Involvement of Trypanosoma cruzi metacyclic trypomastigote surface molecule gp82 in adhesion to gastric mucin and invasion of epithelial cells.
TL;DR: It is suggested that gp82 mediates the interaction of metacyclic trypomastigote surface molecule gp90 or gp35/50 with gastric mucin and the subsequent penetration of underlying epithelial cells.