CHAPTER 24 – Evolution of Protein Molecules

Inference of macromolecular assemblies from crystalline state.

On the Nature of Allosteric Transitions: A Plausible Model

Solvent content of protein crystals.

Stanford Moore, William Stein, and Anfinsen were awarded the Nobel Prize in Chemistry in 1972 for \"their contribution\n to the understanding of the connection between chemical structure and catalytic activity of the active center of the ribonuclease\n molecule.\" In his Nobel Lecture, Anfinsen provided a sketch of the rich history of research that provided the foundation\n for his work on protein folding and the \"Thermodynamic Hypothesis,\" and outlined potential avenues of current and\n future scientific exploration.

https://web.iitd.ac.in/~amittal/1973_Anfinsen_Science.pdf

Principles that Govern the Folding of Protein Chains

Fix L, a haemoglobin that acts as an oxygen sensor: signalling mechanism and structural basis of its homology with PAS domains.

reviewer would suggest that this is a considerable understatement. Two chapters on ‘Basic Theory of Multi-Component Systems’ and ‘Partial Volumes, Density and Refractive-Index Increments’ contain the basic Casassa-Eisenberg treatment, which is extensively called on in the remainder of the book. Further chapters deal with Light and Small-Angle X-Ray Scattering (including a section on fluctuation spectroscopy), Sedimentation Equilibrium, Transport Methods (including sedimentation velocity and diffusion) and Viscosity. This is by no means a book for the experimentalist, for the contents are largely theoretical and selective, and the treatment is highly sophisticated. In a book of this length, complete treatments are not provided, so that, in following a section in detail, excursions to the original journals are frequently necessary to fill the gaps. For this reason alone the book is more difficult than much more comprehensive works. In fact, a first reading of Tanford or similar book might well be recommended as an introduction to the present work. Nevertheless, to the persistent reader, the reward can be great. The standard of production is good, with few errors remaining. The price, however, is almost shocking. Although it is generally accepted nowadays that specialist books are beyond the pocket of the individual, there is now considerable danger that they are going beyond the corporate pocket of the librarian. P. JOHNSON

Haemoglobin: Structure, Function and Synthesis

Erwin Schrodinger's book What is Life?, published in 1944, drew several of the brightest physicists into molecular biology. But the book's chief merit lies in its rescue from obscurity and popularization of an earlier paper by Timofeeff, Zimmer and Delbruck.

Physics and the riddle of life.

Identity of structure of horse deoxy- and oxyhaemoglobin after reaction with bis(N-maleidomethyl)ether.

The number of scientists in the biomedical field is growing exponentially at rates that outstrip funding. The present system of short-term research grants, resulting in armies of postdocs without career prospects, must be changed.

Max F. Perutz

Papers

Fix L, a haemoglobin that acts as an oxygen sensor: signalling mechanism and structural basis of its homology with PAS domains.

Haemoglobin: Structure, Function and Synthesis

Physics and the riddle of life.

Identity of structure of horse deoxy- and oxyhaemoglobin after reaction with bis(N-maleidomethyl)ether.

Will biomedicine outgrow support