Maximilian Tischer

TL;DR: A review of the structure–activity relationships and the modes of action of the various series of mono‐ and bisquaternary ammonium compounds found to have improved antimicrobial activity against mycobacteria and protozoa.

TL;DR: In this article, the structure-activity relationships and the modes of action of various series of (bis)quaternary ammonium compounds are discussed, and a review of their properties is presented.

TL;DR: The data presented suggest that the bisquaternary bisnaphthalimide MT02 exerts anti-Gram-positive activity by binding to DNA and thereby preventing appropriate DNA replication.

TL;DR: The qualitative analysis of the structure-activity relationships (SAR) revealed the importance of a long methylene middle chain of at least 8 methylene groups between the two bisquaternary naphthalimides or a monoquaternaryNaphthalIMide consisting of aLong alkyl chain attached to the positively charged nitrogen atom.

TL;DR: Interestingly, the correlations found between the physico-chemical parameters of the selected compounds and those of commercial molecules that target specific organelles indicate that the rationale might be helpful to drive compound design toward high activities and acceptable pharmacokinetic properties for all compound families.