K
Knut Ohlsen
Researcher at University of Würzburg
Publications - 125
Citations - 6855
Knut Ohlsen is an academic researcher from University of Würzburg. The author has contributed to research in topics: Staphylococcus aureus & Virulence. The author has an hindex of 44, co-authored 116 publications receiving 6012 citations.
Papers
More filters
Journal ArticleDOI
Effect of Subinhibitory Antibiotic Concentrations on Polysaccharide Intercellular Adhesin Expression in Biofilm-Forming Staphylococcus epidermidis
TL;DR: It was shown that S. epidermidis biofilm formation is induced by external stress (i.e., high temperature and osmolarity), and subinhibitory concentrations of tetracycline and the semisynthetic streptogramin antibiotic quinupristin-dalfopristin were found to enhance ica expression.
Journal ArticleDOI
Repair of global regulators in Staphylococcus aureus 8325 and comparative analysis with other clinical isolates
Silvia Herbert,Anne-Kathrin Ziebandt,Knut Ohlsen,Tina Schäfer,Michael Hecker,Dirk Albrecht,Richard P. Novick,Friedrich Götz +7 more
TL;DR: The repaired RN1 is a good model strain for studies of staphylococcal regulation and pathobiology; although strain Newman has been used extensively for such studies in recent years, it has a missense mutation in saeS, the histidine kinase component of the sae signaling module, which profoundly alters its regulatory phenotype.
Journal ArticleDOI
Emergence of methicillin-resistant Staphylococcus aureus (MRSA) in different animal species
Christiane Cuny,Alexander W. Friedrich,Svetlana Kozytska,Franziska Layer,Ulrich Nübel,Knut Ohlsen,Birgit Strommenger,Birgit Walther,Lothar H. Wieler,Wolfgang Witte +9 more
TL;DR: The emergence of methicillin-resistant Staphylococcus aureus in animals such as horses, pet animals and productive livestock has raised questions of a probable human origin and in more general of host specificity of S. aUREus.
Journal ArticleDOI
Alternative transcription factor sigma(B) is involved in regulation of biofilm expression in a Staphylococcus aureus mucosal isolate.
TL;DR: A critical role is suggested in S. aureus biofilm regulation under environmental stress conditions and implementation of the mutant strain with an expression plasmid encoding sigma(B) completely restored the wild-type phenotype.
Journal ArticleDOI
Quaternary Ammonium Salts and Their Antimicrobial Potential: Targets or Nonspecific Interactions?
TL;DR: A review of the structure–activity relationships and the modes of action of the various series of mono‐ and bisquaternary ammonium compounds found to have improved antimicrobial activity against mycobacteria and protozoa.