M
Mechthild Pohlschroder
Researcher at University of Pennsylvania
Publications - 66
Citations - 3510
Mechthild Pohlschroder is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Haloferax volcanii & Twin-arginine translocation pathway. The author has an hindex of 28, co-authored 58 publications receiving 3225 citations. Previous affiliations of Mechthild Pohlschroder include Harvard University & University of Massachusetts Amherst.
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Journal ArticleDOI
Genome sequence of Halobacterium species NRC-1
Wailap Victor Ng,Wailap Victor Ng,Sean Kennedy,Gregory G. Mahairas,Gregory G. Mahairas,Brian R. Berquist,Min Pan,Min Pan,Hem D. Shukla,Stephen R. Lasky,Stephen R. Lasky,Nitin S. Baliga,Vesteinn Thorsson,Vesteinn Thorsson,Jennifer L. Sbrogna,Steven Swartzell,Douglas Weir,John A. Hall,Timothy A. Dahl,Timothy A. Dahl,Russell Welti,Russell Welti,Young Ah Goo,Young Ah Goo,Brent Leithauser,Kim Keller,Randy Cruz,Michael J. Danson,David W. Hough,Deborah G. Maddocks,Peter E. Jablonski,Mark P. Krebs,Christine M. Angevine,Heather Dale,Thomas A. Isenbarger,Ronald F. Peck,Mechthild Pohlschroder,John L. Spudich,Kwang Hwan Jung,Maqsudul Alam,Tracey Allen K. Freitas,Shaobin Hou,Charles J. Daniels,Patrick P. Dennis,Arina D. Omer,Holger Ebhardt,Todd M. Lowe,Ping Liang,Monica Riley,Leroy Hood,Leroy Hood,Shiladitya DasSarma +51 more
TL;DR: Analysis of the genome sequence shows the presence of pathways for uptake and utilization of amino acids, active sodium-proton antiporter and potassium uptake systems, sophisticated photosensory and signal transduction pathways, and DNA replication, transcription, and translation systems resembling more complex eukaryotic organisms.
Journal ArticleDOI
Adaptation of protein secretion to extremely high-salt conditions by extensive use of the twin-arginine translocation pathway.
TL;DR: Data is presented suggesting that the utilization of protein translocation pathways for protein secretion by the Halobacteriaceae differs significantly from that of non‐haloarchaea, and most probably represents an adaptation to the high‐salt environment.
Journal ArticleDOI
Prokaryotic Utilization of the Twin-Arginine Translocation Pathway: a Genomic Survey
TL;DR: While many prokaryotes use this pathway predominantly for the secretion of redox proteins, analyses of the predicted substrates suggest that certain bacteria and archaea secrete mainly nonredox proteins via the Tat pathway.
Journal ArticleDOI
Protein Translocation in the Three Domains of Life: Variations on a Theme
TL;DR: This work compared sequences of known translocation components with genome sequences of M. jannaschii, M. thermoautotrophicum, and P. aerofilum to find patterns that can be attributed to translocation-based signaling pathways in E. coli.
Journal ArticleDOI
The twin-arginine translocation pathway is a major route of protein export in Streptomyces coelicolor
David A. Widdick,Kieran Dilks,Govind Chandra,Andrew R. Bottrill,Mike J. Naldrett,Mechthild Pohlschroder,Tracy Palmer,Tracy Palmer +7 more
TL;DR: Experimental evidence is provided that the Tat system is used as a major general export pathway in Streptomyces and putative lipoproteins were shown to be Tat-dependent.