Min Pan

TL;DR: It is shown that oxidation–reduction cycles of peroxiredoxin proteins constitute a universal marker for circadian rhythms in all domains of life, by characterizing their oscillations in a variety of model organisms and exploring the interconnectivity between these metabolic cycles and transcription–translation feedback loops of the clockwork in each system.

TL;DR: Analysis of the genome sequence shows the presence of pathways for uptake and utilization of amino acids, active sodium-proton antiporter and potassium uptake systems, sophisticated photosensory and signal transduction pathways, and DNA replication, transcription, and translation systems resembling more complex eukaryotic organisms.

TL;DR: This study supports the claim that the high degree of connectivity within biological and EF networks will enable the construction of similar models for any organism from relatively modest numbers of experiments.

TL;DR: In comparing the physiologies of the two halophilic archaea, in addition to the expected extensive similarity, it is discovered several differences in their metabolic strategies and physiological responses such as distinct pathways for arginine breakdown in each halophile.

TL;DR: The utility of FIRM is demonstrated by inferring a cancer-miRNA regulatory network through the analysis of 2240 gene coexpression signatures from 46 cancers and a subset of 13 miRNAs that regulate oncogenic processes across diverse cancers are discovered.