M
Meenu Kesarwani
Researcher at Cincinnati Children's Hospital Medical Center
Publications - 12
Citations - 367
Meenu Kesarwani is an academic researcher from Cincinnati Children's Hospital Medical Center. The author has contributed to research in topics: Leukemia & Oxalate decarboxylase. The author has an hindex of 8, co-authored 12 publications receiving 296 citations. Previous affiliations of Meenu Kesarwani include Jawaharlal Nehru University.
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Journal ArticleDOI
Oxalate decarboxylase from Collybia velutipes. Molecular cloning and its overexpression to confer resistance to fungal infection in transgenic tobacco and tomato.
TL;DR: Transgenic tobacco and tomato plants expressing oxalate decarboxylase show remarkable resistance to phytopathogenic fungus Sclerotinia sclerotiorum that utilizes oxalic acid during infestation.
Journal ArticleDOI
Targeting c-FOS and DUSP1 abrogates intrinsic resistance to tyrosine-kinase inhibitor therapy in BCR-ABL-induced leukemia
Meenu Kesarwani,Zachary Kincaid,Ahmed Gomaa,Erika Huber,Sara Rohrabaugh,Zain Siddiqui,Muhammad F. Bouso,Tahir Latif,Ming Xu,Kakajan Komurov,James C. Mulloy,Jose A. Cancelas,H. Leighton Grimes,Mohammad Azam +13 more
TL;DR: It is shown that oncogenic kinase and growth-factor signaling converge to induce the expression of the signaling proteins FBJ osteosarcoma oncogene (c-FOS, encoded by Fos) and dual-specificity phosphatase 1 (DUSP1), which might represent a unifying Achilles' heel of kinase-driven cancers.
Journal ArticleDOI
Targeting substrate-site in Jak2 kinase prevents emergence of genetic resistance.
Meenu Kesarwani,Erika Huber,Zachary Kincaid,Chris R. Evelyn,Jacek Biesiada,Mark Rance,Mahendra Thapa,Neil P. Shah,Jarek Meller,Yi Zheng,Mohammad Azam,Mohammad Azam +11 more
TL;DR: This work reports a novel mechanism of JAK2 kinase inhibition by fedratinib that prevents emergence of genetic resistance and suggests that in order to develop resistance-free kinase inhibitors, the next-generation drug design should target the substrate-binding site.
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Cloning and characterization of the 5'-flanking region of the oxalate decarboxylase gene from Flammulina velutipes.
TL;DR: Results suggest that in F. velutipes cells, activation of OXDC transcription in response to low pH is mediated by the binding of a novel transcription factor through the LPRE site in the OxDC promoter.
Journal ArticleDOI
The high NRF2 expression confers chemotherapy resistance partly through up-regulated DUSP1 in myelodysplastic syndromes
Peipei Lin,Yanling Ren,Xiaomei Yan,Yingwan Luo,Hua Zhang,Meenu Kesarwani,Jiachen Bu,Di Zhan,Yile Zhou,Yile Zhou,Yuting Tang,Shuanghong Zhu,Weilai Xu,Xinping Zhou,Chen Mei,Liya Ma,Li Ye,Chao Hu,Mohammad Azam,Wei Ding,Jie Jin,Gang Huang,Hongyan Tong +22 more
TL;DR: This study found that NRF2 expression levels in bone marrow from high-risk patients exceeded that of low-risk MDS patients, and suggested that targetingNRF2 in combination with conventional chemotherapy could pave the way for future therapy for high- risk MDS.