M
Mohammad Azam
Researcher at King Saud University
Publications - 261
Citations - 7497
Mohammad Azam is an academic researcher from King Saud University. The author has contributed to research in topics: Chemistry & Medicine. The author has an hindex of 31, co-authored 204 publications receiving 5923 citations. Previous affiliations of Mohammad Azam include Massachusetts Institute of Technology & Cincinnati Children's Hospital Medical Center.
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Journal ArticleDOI
Lin28 promotes transformation and is associated with advanced human malignancies
Srinivas R. Viswanathan,John T. Powers,William S. Einhorn,Yujin Hoshida,Tony Ng,Sara Toffanin,Maureen J. O'Sullivan,Jun Lu,Letha A. Phillips,Victoria L Lockhart,Samar P. Shah,Pradeep S. Tanwar,Craig H. Mermel,Rameen Beroukhim,Mohammad Azam,José A. Teixeira,Matthew Meyerson,Timothy P. Hughes,Josep M. Llovet,Jerald P. Radich,Charles G. Mullighan,Todd R. Golub,Poul H. Sorensen,George Q. Daley +23 more
TL;DR: This work provides a mechanism for the coordinate repression of let-7 miRNAs observed in a subset of human cancers, and associates activation of LIN28 and LIN28B with poor clinical prognosis.
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Mechanisms of autoinhibition and STI-571/imatinib resistance revealed by mutagenesis of BCR-ABL
TL;DR: An in vitro screen of randomly mutagenized BCR-ABL is performed and all of the major mutations previously identified in patients and numerous others that illuminate novel mechanisms of acquired drug resistance are recovered.
Journal ArticleDOI
Targeting Bcr–Abl by combining allosteric with ATP-binding-site inhibitors
Jianming Zhang,Francisco Adrian,Wolfgang Jahnke,Sandra W. Cowan-Jacob,Allen G. Li,Roxana E. Iacob,Taebo Sim,Taebo Sim,John T. Powers,John T. Powers,Christine Dierks,Fangxian Sun,Gui Rong Guo,Qiang Ding,Barun Okram,Yongmun Choi,Amy Wojciechowski,Xianming Deng,Guoxun Liu,Gabriele Fendrich,André Strauss,Navratna Vajpai,Stephan Grzesiek,Tove Tuntland,Yi Liu,Badry Bursulaya,Mohammad Azam,Mohammad Azam,Paul W. Manley,John R. Engen,George Q. Daley,George Q. Daley,Markus Warmuth,Nathanael S. Gray +33 more
TL;DR: The results show that therapeutically relevant inhibition of Bcr–Abl activity can be achieved with inhibitors that bind to the myristate-binding site and that combining allosteric and ATP-competitive inhibitors can overcome resistance to either agent alone.
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Activation of tyrosine kinases by mutation of the gatekeeper threonine
TL;DR: It is demonstrated that mutation of the gatekeeper threonine is a common mechanism of activation for tyrosine kinases and structural insights are provided to guide the development of next-generation inhibitors.
Journal ArticleDOI
Interleukin-3 signals through multiple isoforms of Stat5.
Mohammad Azam,H. Erdjument-Bromage,B. L. Kreider,Min Xia,Frederick W. Quelle,Reetobrata Basu,C. Saris,P. Tempst,James N. Ihle,Christian Schindler +9 more
TL;DR: Peptide sequence data obtained from the purified 77 and 80 kDa proteins (p77 and p80) indicate that they are closely related but are encoded by distinct genes, and these two proteins are the murine homologs of ovine mammary gland factor (MGF)/Stat5.