J
Jarek Meller
Researcher at University of Cincinnati
Publications - 58
Citations - 2555
Jarek Meller is an academic researcher from University of Cincinnati. The author has contributed to research in topics: Autophagy & Phosphorylation. The author has an hindex of 22, co-authored 58 publications receiving 2193 citations. Previous affiliations of Jarek Meller include University of Cincinnati Academic Health Center & Cincinnati Children's Hospital Medical Center.
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Journal ArticleDOI
Hypomorphic mutations in PRF1, MUNC13-4, and STXBP2 are associated with adult-onset familial HLH
Kejian Zhang,Michael B. Jordan,Rebecca A. Marsh,Judith Johnson,Diane Kissell,Jarek Meller,Joyce Villanueva,Kimberly A. Risma,Qian Wei,Peter S. Klein,Alexandra H. Filipovich +10 more
TL;DR: The preponderance of hypomorphic mutations in familial HLH-causing genes correlates with the later-onset clinical symptoms and the more indolent course in adult patients, and it is concluded that late-ONSet familial HLh occurs more commonly than was suspected previously.
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VHL-regulated MiR-204 suppresses tumor growth through inhibition of LC3B-mediated autophagy in renal clear cell carcinoma.
Olga Mikhaylova,Yiwen Stratton,Daniel Hall,Emily Kellner,Birgit Ehmer,Angela F. Drew,Catherine A. Gallo,David R. Plas,Jacek Biesiada,Jarek Meller,Jarek Meller,Maria F. Czyzyk-Krzeska,Maria F. Czyzyk-Krzeska +12 more
TL;DR: It is shown that miR-204 is a VHL-regulated tumor suppressor acting by inhibiting macroautophagy, with MAP1LC3B ( LC3B) as a direct and functional target.
Journal ArticleDOI
Rotavirus VP8*: phylogeny, host range, and interaction with histo-blood group antigens
Yang Liu,Pengwei Huang,Ming Tan,Yiliu Liu,Jacek Biesiada,Jarek Meller,Alejandro A. Castello,Baoming Jiang,Xi Jiang +8 more
TL;DR: A phylogenetic analysis of RVs and further variations of RV interaction with HBGAs are shown, suggesting thatHBGAs play an important role in RV infection and evolution.
Journal ArticleDOI
TRPM3 and miR-204 Establish a Regulatory Circuit that Controls Oncogenic Autophagy in Clear Cell Renal Cell Carcinoma
Daniel Hall,Nicholas G. Cost,Nicholas G. Cost,Shailaja Hegde,Emily Kellner,Olga Mikhaylova,Yiwen Stratton,Birgit Ehmer,William Abplanalp,Raghav Pandey,Jacek Biesiada,Christian Harteneck,David R. Plas,Jarek Meller,Jarek Meller,Jarek Meller,Maria F. Czyzyk-Krzeska,Maria F. Czyzyk-Krzeska +17 more
TL;DR: Using shRNAs, a dominant-negative mutant, and a pharmacologic inhibitor, mefenamic acid (MFA), it is established that the Transient Receptor Potential Melastatin 3 (TRPM3) channel promotes the growth of clear cell renal cell carcinoma (ccRCC) and stimulates MAP1LC3A ( LC3A) and MAP1 LC3B (LC3B) autophagy.
Journal ArticleDOI
Localization of Rac2 via the C terminus and aspartic acid 150 specifies superoxide generation, actin polarity and chemotaxis in neutrophils.
TL;DR: Specific sequences in Rac are defined that specify subcellular localization and determine the specificity of Rac2 in neutrophil chemotaxis and superoxide generation.