Megan van Overbeek

TL;DR: The findings establish a mechanistic paradigm for the recombination of sex chromosomes during meiosis in mice by proposing that the repetitive DNA sequence of the PAR confers unique chromatin and higher-order structures that are crucial for recombination.

TL;DR: This work demonstrates how Saccharomyces cerevisiae integrates multiple temporally distinct pathways to regulate the binding of Rec114 and Mer2 to chromosomes, thereby controlling the duration of a DSB-competent state.

TL;DR: It is proposed that meiotic recombination is an important component of host-Ty interactions and that Tys play critical roles in genome instability and evolution in both inbred and outcrossed sexual cycles.

TL;DR: It is proposed that the repetitive PAR sequence confers unique chromatin and higher order structures crucial for DSB formation, X–Y pairing, and recombination, which establish a mechanistic paradigm of mammalian sex chromosome segregation during spermatogenesis.

TL;DR: It is demonstrated that Saccharomyces cerevisiae integrates multiple, temporally distinct pathways to regulate chromosomal binding of pro-DSB factors Rec114 and Mer2, thereby controlling duration of a DSB-competent state.