M
Mariko Sasaki
Researcher at Memorial Sloan Kettering Cancer Center
Publications - 4
Citations - 836
Mariko Sasaki is an academic researcher from Memorial Sloan Kettering Cancer Center. The author has contributed to research in topics: Homologous recombination & Genome evolution. The author has an hindex of 4, co-authored 4 publications receiving 757 citations. Previous affiliations of Mariko Sasaki include Cornell University.
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Journal ArticleDOI
A hierarchical combination of factors shapes the genome-wide topography of yeast meiotic recombination initiation.
Jing Pan,Mariko Sasaki,Mariko Sasaki,Ryan Kniewel,Ryan Kniewel,Hajime Murakami,Hannah G. Blitzblau,Sam E. Tischfield,Sam E. Tischfield,Xuan Zhu,Xuan Zhu,Matthew J. Neale,Matthew J. Neale,Maria Jasin,Nicholas D. Socci,Andreas Hochwagen,Scott Keeney +16 more
TL;DR: This analysis offers mechanistic insight into DSB formation and early processing steps, supporting the view that the recombination terrain is molded by combinatorial and hierarchical interaction of factors that work on widely different size scales.
Journal ArticleDOI
Genome destabilization by homologous recombination in the germ line.
TL;DR: Research in yeast has provided insights into the molecular mechanisms of meiotic NAHR as well as the cellular strategies that limit it, which have been implicated in numerous human genetic disorders.
Journal ArticleDOI
Evolutionarily diverse determinants of meiotic DNA break and recombination landscapes across the genome
TL;DR: DSBs are determined genome-wide at near-nucleotide resolution by sequencing the oligonucleotides attached to Rec12 following DNA cleavage, and it is demonstrated that evolutionarily fluid factors contribute to crossover initiation and regulation.
Journal ArticleDOI
Meiotic Recombination Initiation in and around Retrotransposable Elements in Saccharomyces cerevisiae
Mariko Sasaki,Sam E. Tischfield,Sam E. Tischfield,Megan van Overbeek,Scott Keeney,Scott Keeney +5 more
TL;DR: It is proposed that meiotic recombination is an important component of host-Ty interactions and that Tys play critical roles in genome instability and evolution in both inbred and outcrossed sexual cycles.