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Isabel Lam
Researcher at Memorial Sloan Kettering Cancer Center
Publications - 18
Citations - 1238
Isabel Lam is an academic researcher from Memorial Sloan Kettering Cancer Center. The author has contributed to research in topics: Homologous recombination & Meiosis. The author has an hindex of 10, co-authored 17 publications receiving 1081 citations. Previous affiliations of Isabel Lam include New York University & Brigham and Women's Hospital.
Papers
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Journal ArticleDOI
Mechanism and Regulation of Meiotic Recombination Initiation
Isabel Lam,Scott Keeney +1 more
TL;DR: This review summarizes recent studies pertaining to the formation of meiotic DSBs, including the mechanism of DNA cleavage by Spo11, proteins required for break formation, and mechanisms that control the location, timing, and number of D SBs.
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Nodes of Ranvier and axon initial segments are ankyrin G–dependent domains that assemble by distinct mechanisms
Yulia Dzhashiashvili,Yanqing Zhang,Jolanta Galinska,Isabel Lam,Martin Grumet,Martin Grumet,James L. Salzer +6 more
TL;DR: It is shown that the AIS and peripheral nervous system (PNS) nodes both require ankyrin G but assemble by distinct mechanisms, whereas PNS nodes assemble from the outside in, specified by Schwann cells, which direct the NF186-dependent recruitment of ankyr in G.
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Nectin-like proteins mediate axon Schwann cell interactions along the internode and are essential for myelination.
Patrice Maurel,Steven Einheber,Jolanta Galinska,Pratik Thaker,Isabel Lam,Marina Rubin,Steven S. Scherer,Yoshinuri Murakami,David H. Gutmann,James L. Salzer +9 more
TL;DR: A key role for Necl-4 in initiating peripheral nervous system myelination is demonstrated and the Necl proteins as mediators of axo–glial interactions along the internode are implicate.
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The kinetochore prevents centromere-proximal crossover recombination during meiosis
Nadine Vincenten,Lisa Marie Kuhl,Isabel Lam,Ashwini Oke,Alastair R.W. Kerr,Andreas Hochwagen,Jennifer C. Fung,Scott Keeney,Gerben Vader,Adele L. Marston +9 more
TL;DR: This work identifies the conserved CTF19/CCAN kinetochore sub-complex as a major factor that minimizes potentially deleterious centromere-proximal crossovers in budding yeast and uncovers multi-layered suppression of pericentromeric recombination by the Ctf19 complex, operating across distinct chromosomal distances.
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Nonparadoxical evolutionary stability of the recombination initiation landscape in yeast
Isabel Lam,Scott Keeney +1 more
TL;DR: Comparison of genome-wide recombination initiation maps from widely divergent Saccharomyces species finds that hotspots frequently overlap with promoters in the species tested, and consequently, hotspot positions are well conserved.