M
Mehdi van den Bos
Researcher at University of Sydney
Publications - 21
Citations - 585
Mehdi van den Bos is an academic researcher from University of Sydney. The author has contributed to research in topics: Amyotrophic lateral sclerosis & Transcranial magnetic stimulation. The author has an hindex of 10, co-authored 21 publications receiving 292 citations. Previous affiliations of Mehdi van den Bos include Westmead Hospital.
Papers
More filters
Journal ArticleDOI
TDP-43 proteinopathies: a new wave of neurodegenerative diseases.
Eva M.J. de Boer,Viyanti K Orie,Tim Williams,Mark R. Baker,Hugo M De Oliveira,Tuomo Polvikoski,Matthew Silsby,Parvathi Menon,Mehdi van den Bos,Glenda M. Halliday,Leonard H. van den Berg,Ludo Van Den Bosch,Philip Van Damme,Matthew C. Kiernan,Michael A van Es,Steve Vucic +15 more
TL;DR: This review highlights the key physiological functions of the TDP-43 protein, while considering an expanding spectrum of neurodegenerative diseases associated with pathogenic T DP-43 deposition, and dissecting key molecular pathways through which TD-43 may mediate neurodegenersation.
Journal ArticleDOI
Pathophysiology and Diagnosis of ALS: Insights from Advances in Neurophysiological Techniques.
TL;DR: An overview of key advances in the understanding of ALS pathophysiology and diagnosis is provided, focusing on the importance of cortical hyperexcitability and its relationship to advances in genetic and molecular processes implicated in ALS pathogenesis.
Journal ArticleDOI
Riluzole exerts transient modulating effects on cortical and axonal hyperexcitability in ALS.
Nimeshan Geevasinga,Parvathi Menon,Karl Ng,Mehdi van den Bos,Karen Byth,Matthew C. Kiernan,Steve Vucic +6 more
TL;DR: It is established that riluzole exerts transient effects on cortical and axonal hyperexcitability, potentially accounting for the modest clinical effectiveness in ALS.
Journal ArticleDOI
Imbalance of cortical facilitatory and inhibitory circuits underlies hyperexcitability in ALS
Mehdi van den Bos,Mana Higashihara,Nimeshan Geevasinga,Parvathi Menon,Matthew C. Kiernan,Steve Vucic +5 more
TL;DR: It is established that cortical hyperexcitability is a key contributor to ALS pathophysiology, mediated through dysfunction of inhibitory and facilitatory intracortical circuits, and therapies aimed at restoring the cortical inhibitory imbalance provide novel avenues for future therapeutic targets.
Journal ArticleDOI
Diagnostic Utility of Gold Coast Criteria in Amyotrophic Lateral Sclerosis.
Andrew Hannaford,Nathan Pavey,Mehdi van den Bos,Nimeshan Geevasinga,Parvathi Menon,Jeremy M. Shefner,Matthew C. Kiernan,Steve Vucic +7 more
TL;DR: In this article, the diagnostic utility of the recently proposed Gold Coast criteria was determined in ALS, with benefits evident in bulbar and limb onset disease patients, as well as atypical phenotypes.