M
Mehmet Gunduz
Researcher at Wakayama Medical University
Publications - 261
Citations - 6539
Mehmet Gunduz is an academic researcher from Wakayama Medical University. The author has contributed to research in topics: Cancer & Loss of heterozygosity. The author has an hindex of 35, co-authored 255 publications receiving 6096 citations. Previous affiliations of Mehmet Gunduz include Turgut Özal University & University of Texas MD Anderson Cancer Center.
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Journal ArticleDOI
Dual regulation of Snail by GSK-3β-mediated phosphorylation in control of epithelial–mesenchymal transition
TL;DR: It is shown that GSK-3β binds to and phosphorylates Snail at two consensus motifs to dually regulate the function of this protein and together function as a molecular switch for many signalling pathways that lead to EMT.
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Nuclear interaction of EGFR and STAT3 in the activation of the iNOS/NO pathway.
Hui-Wen Lo,Sheng-Chieh Hsu,Mohamed Ali-Seyed,Mehmet Gunduz,Weiya Xia,Yongkun Wei,Geoffrey Bartholomeusz,Jin-Yuan Shih,Mien Chie Hung +8 more
TL;DR: It is reported that EGFR physically interacts with signal transducers and activators of transcription 3 (STAT3) in the nucleus, leading to transcriptional activation of inducible nitric oxide synthase (iNOS) in breast carcinomas.
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C-kit protein expression correlated with activating mutations in KIT gene in oral mucosal melanoma
Rosario Santos Rivera,Hitoshi Nagatsuka,Mehmet Gunduz,Beyhan Cengiz,Esra Gunduz,Chong Huat Siar,Hidetsugu Tsujigiwa,Ryo Tamamura,Kok Ng Han,Noriyuki Nagai +9 more
TL;DR: C-kit expression in atypical melanocytes suggests the role of c-kit in the early stage of OMM tumorigenesis, and protein expression correlated with activating mutations indicating the pertinent role of the proto-oncogene KIT in the tumors of O MM.
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Genomic structure of the human ING1 gene and tumor-specific mutations detected in head and neck squamous cell carcinomas.
Mehmet Gunduz,Mamoru Ouchida,Kunihiro Fukushima,Hiroko Hanafusa,Tsutomu Etani,Shinji Nishioka,Kazunori Nishizaki,Kenji Shimizu +7 more
TL;DR: The first report that three missense mutations and three silent changes were detected in the ING1 gene in 6 of 23 tumors with allelic loss at the 13q33-34 region is presented.
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Heparanase Expression Correlates with Invasion and Poor Prognosis in Gastric Cancers
Munenori Takaoka,Yoshio Naomoto,Takaomi Ohkawa,Hirokazu Uetsuka,Yasuhiro Shirakawa,Futoshi Uno,Toshiyoshi Fujiwara,Mehmet Gunduz,Hitoshi Nagatsuka,Motowo Nakajima,Noriaki Tanaka,Minoru Haisa +11 more
TL;DR: Analysis of the clinicopathologic features showed stronger heparanase expression in cases of huge growing tumors, extensive invasion to lymph vessels, and regional lymph node metastasis, suggesting that high expression of heparAnase in gastric cancer is a strong predictor of poor survival.