M
Mehmet Kanbay
Researcher at Koç University
Publications - 438
Citations - 12822
Mehmet Kanbay is an academic researcher from Koç University. The author has contributed to research in topics: Kidney disease & Medicine. The author has an hindex of 54, co-authored 370 publications receiving 9894 citations. Previous affiliations of Mehmet Kanbay include Bellvitge University Hospital & Fatih University.
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Journal ArticleDOI
Uric Acid Induces Hepatic Steatosis by Generation of Mitochondrial Oxidative Stress POTENTIAL ROLE IN FRUCTOSE-DEPENDENT AND -INDEPENDENT FATTY LIVER
Miguel A. Lanaspa,Laura G. Sánchez-Lozada,Yea Jin Choi,Christina Cicerchi,Mehmet Kanbay,Carlos A. Roncal-Jimenez,Takuji Ishimoto,Nanxing Li,George Marek,Murat Duranay,George F. Schreiner,Bernardo Rodriguez-Iturbe,Takahiko Nakagawa,Duk Hee Kang,Yuri Y. Sautin,Richard J. Johnson +15 more
TL;DR: It is shown that fructose also stimulates triglyceride synthesis via a purine-degrading pathway that is triggered from the rapid phosphorylation of fructose by fructokinase, which provides new insights into the pathogenesis of hepatic fat accumulation under normal and diseased states.
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The role of uric acid in the pathogenesis of human cardiovascular disease
Mehmet Kanbay,Mark S. Segal,Baris Afsar,Duk Hee Kang,Bernardo Rodriguez-Iturbe,Richard J. Johnson +5 more
TL;DR: Uric acid may also have emerging roles in the pathogenesis of kidney disease, metabolic syndrome and diabetes and more studies need to be performed on the pathophysiology and clinical consequences of hyperuricaemia in cardiovascular disease.
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Epidemiology, contributors to, and clinical trials of mortality risk in chronic kidney failure
Alberto Ortiz,Adrian Covic,Danilo Fliser,Denis Fouque,David Goldsmith,Mehmet Kanbay,Francesca Mallamaci,Ziad A. Massy,Ziad A. Massy,Patrick Rossignol,Raymond Vanholder,Andrzej Wiecek,Carmine Zoccali,Gérard M. London +13 more
TL;DR: Policy changes to improve access to renal replacement therapy should be combined with research into low-cost renal replacement Therapy and optimum clinical care, which should include multifaceted approaches simultaneously targeting several of the putative contributors to increased mortality.
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Effect of treatment of hyperuricemia with allopurinol on blood pressure, creatinine clearence, and proteinuria in patients with normal renal functions.
Mehmet Kanbay,Adem Özkara,Yusuf Selcoki,Bunyamin Isik,Faruk Turgut,Nuket Bavbek,Ebru Uz,Ali Akcay,Ramazan Yigitoglu,Adrian Covic +9 more
TL;DR: In this paper, the benefits of allopurinol treatment in hyperuricemic patients with normal renal function were investigated for patients with glomerular filtration rate (GFR) > 60 ml/min.
Journal ArticleDOI
Recovery of Kidney Function After Acute Kidney Injury in the Elderly: A Systematic Review and Meta-analysis
Roland Schmitt,Steven G. Coca,Mehmet Kanbay,Mary E. Tinetti,Lloyd G. Cantley,Chirag R. Parikh +5 more
TL;DR: There is impaired recovery of kidney function after AKI in aged individuals and future studies should be cognizant of "age" as a potential effect modifier in the prognosis after AKi, and clinical trials should focus on improving outcomes in the elderly cohort.