Journal ArticleDOI
Effect of treatment of hyperuricemia with allopurinol on blood pressure, creatinine clearence, and proteinuria in patients with normal renal functions.
Mehmet Kanbay,Adem Özkara,Yusuf Selcoki,Bunyamin Isik,Faruk Turgut,Nuket Bavbek,Ebru Uz,Ali Akcay,Ramazan Yigitoglu,Adrian Covic +9 more
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TLDR
In this paper, the benefits of allopurinol treatment in hyperuricemic patients with normal renal function were investigated for patients with glomerular filtration rate (GFR) > 60 ml/min.Abstract:
Background
Hyperuricemia has been associated with the development of hypertension, cardiovascular, and renal disease. However, there is no data about the effect of lowering uric acid level on hypertension, renal function, and proteinuria in patients with glomerular filtration rate (GFR) >60 ml/min. We therefore conducted a prospective study to investigate the benefits of allopurinol treatment in hyperuricemic patients with normal renal function.read more
Citations
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Journal ArticleDOI
Uric acid and cardiovascular risk.
TL;DR: This review summarizes relevant studies concerning uric acid and possible links to hypertension, renal disease, and cardiovascular disease and presents current evidence.
Journal ArticleDOI
Effect of Allopurinol in Chronic Kidney Disease Progression and Cardiovascular Risk
Marian Goicoechea,Soledad García de Vinuesa,Ursula Verdalles,Caridad Ruiz-Caro,Jara Ampuero,Abraham Rincón,David Arroyo,José Luño +7 more
TL;DR: Allopurinol decreases C-reactive protein and slows down the progression of renal disease in patients with chronic kidney disease and reduces cardiovascular and hospitalization risk in these subjects.
Journal ArticleDOI
Elevated Uric Acid Increases the Risk for Kidney Disease
Rudolf P. Obermayr,Christian Temml,Georg Gutjahr,Maarten Knechtelsdorfer,Rainer Oberbauer,Renate Klauser-Braun +5 more
TL;DR: Evaluated data from 21,475 healthy volunteers showed that elevated levels of uric acid independently increase the risk for new-onset kidney disease.
Journal ArticleDOI
Uric Acid Induces Hepatic Steatosis by Generation of Mitochondrial Oxidative Stress POTENTIAL ROLE IN FRUCTOSE-DEPENDENT AND -INDEPENDENT FATTY LIVER
Miguel A. Lanaspa,Laura G. Sánchez-Lozada,Yea Jin Choi,Christina Cicerchi,Mehmet Kanbay,Carlos A. Roncal-Jimenez,Takuji Ishimoto,Nanxing Li,George Marek,Murat Duranay,George F. Schreiner,Bernardo Rodriguez-Iturbe,Takahiko Nakagawa,Duk Hee Kang,Yuri Y. Sautin,Richard J. Johnson +15 more
TL;DR: It is shown that fructose also stimulates triglyceride synthesis via a purine-degrading pathway that is triggered from the rapid phosphorylation of fructose by fructokinase, which provides new insights into the pathogenesis of hepatic fat accumulation under normal and diseased states.
References
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Gout-associated uric acid crystals activate the NALP3 inflammasome
TL;DR: It is shown that MSU and CPPD engage the caspase-1-activating NALP3 (also called cryopyrin) inflammasome, resulting in the production of active interleukin (IL)-1β and IL-18 in mice deficient in the IL-1β receptor.
Journal Article
A simplified equation to predict glomerular filtration rate from serum creatinine
Andrew S. Levey,Juan P. Bosch,Julia B. Lewis,Shahriari Ali Reza,Nancy L. Rogers,David M. Roth +5 more
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Molecular identification of a danger signal that alerts the immune system to dying cells
TL;DR: Uric acid stimulates dendritic cell maturation and, when co-injected with antigen in vivo, significantly enhances the generation of responses from CD8+ T cells, and have important implications for vaccines, autoimmunity and inflammation.
Journal ArticleDOI
Absence of Monocyte Chemoattractant Protein-1 Reduces Atherosclerosis in Low Density Lipoprotein Receptor–Deficient Mice
Long Gu,Yoshikatsu Okada,Steven K. Clinton,Craig Gerard,Galina K. Sukhova,Peter Libby,Barrett J. Rollins +6 more
TL;DR: Monocyte chemoattractant protein-1 plays a unique and crucial role in the initiation of atherosclerosis and may provide a new therapeutic target in this disorder.
Journal ArticleDOI
Is There a Pathogenetic Role for Uric Acid in Hypertension and Cardiovascular and Renal Disease
Richard J. Johnson,Duk Hee Kang,Daniel I. Feig,Salah D. Kivlighn,John Kanellis,Susumu Watanabe,Katherine R. Tuttle,Bernardo Rodriguez-Iturbe,Jaime Herrera-Acosta,Marilda Mazzali +9 more
TL;DR: It is time to reevaluate the role of uric acid as a risk factor for cardiovascular disease and hypertension and to design human studies to address this controversy.