A review on the development of urease inhibitors as antimicrobial agents against pathogenic bacteria.

Discovery of novel arylethenesulfonyl fluorides as potential candidates against methicillin-resistant of Staphylococcus aureus (MRSA) for overcoming multidrug resistance of bacterial infections.

Hydrated and anhydrous cobalt (II) barbiturates: Crystal structures, spectroscopic and thermal properties

In this study, we have successfully synthesized a gemini quaternary ammonium salt C24H38O4N2Br2 and applied it to wool fabric to obtain antibacterial properties. First, tris(2-carboxyethyl)phosphine (TCEP) was utilized as a reducing agent to generate thiol groups on the surface of the wool fabric. Then, these thiol groups reacted with CC groups of the gemini quaternary ammonium salt via click chemistry. The structure of the as-prepared ionic dimethacrylate (IDMA) monomers was characterized using FT-IR spectroscopy, 1H-NMR analysis, mass spectrometry and elemental analysis. The modified wool fabric exhibited good anti-bacterial properties against both E. coli and S. aureus. Furthermore, the modified fabric exhibits good antistatic properties and its mechanical properties are improved by the chemical bonds of the modification.

Synthesis of a gemini quaternary ammonium salt and its reaction with wool fabric using click chemistry

A series of 27 new barbiturates and thiobarbiturates have been synthesized by a convenient multi-component reaction in overall excellent yields (87-96%). All the synthesized compounds were characterized by 1H, 13C NMR, EIMS and elemental analysis (C, H, N and S). Furthermore, all compounds were screened for in vitro antioxidant (DPPH radical scavenging), lipoxygenase, chymotrypsin, α-glucosidase and anti-urease activities. Out of the series, 23 in DPPH, 14 in lipoxygenase, 2 in chymotrypsin have shown appreciable IC50 values.

https://www.tandfonline.com/doi/pdf/10.3109/14756366.2014.895717

Mehmood Qadir

Papers

Antimicrobial Efficacy of Metal-Barbiturate Conjugates Against Pathogenic Strains of Escherichia coli and Staphylococcus aureus