M
Mehrdad Matloubian
Researcher at University of California, San Francisco
Publications - 58
Citations - 11803
Mehrdad Matloubian is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Cytotoxic T cell & Lymphocytic choriomeningitis. The author has an hindex of 33, co-authored 47 publications receiving 10581 citations. Previous affiliations of Mehrdad Matloubian include Emory University & University of California, Los Angeles.
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Journal ArticleDOI
Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1
Mehrdad Matloubian,Charles G. Lo,Guy Cinamon,Matthew J. Lesneski,Ying Xu,Volker Brinkmann,Maria L. Allende,Richard L. Proia,Jason G. Cyster +8 more
TL;DR: It is established that S1P1 is essential for lymphocyte recirculation and that it regulates egress from both thymus and peripheral lymphoid organs.
Journal ArticleDOI
CD4+ T cells are required to sustain CD8+ cytotoxic T-cell responses during chronic viral infection.
TL;DR: It is shown that CD4+ T cells are dispensable for short-term acute infection in which CD8+ CTL activity does not need to be sustained for more than 2 weeks, but under conditions of chronic infection, in which it takes several months or longer to clear the infection, CD4-cell function is critical.
Journal ArticleDOI
CD69 acts downstream of interferon-alpha/beta to inhibit S1P1 and lymphocyte egress from lymphoid organs.
Lawrence R. Shiow,David B. Rosen,Naděžda Brdičková,Ying Xu,Jinping An,Lewis L. Lanier,Jason G. Cyster,Mehrdad Matloubian +7 more
TL;DR: Treatment with the IFN-α/β inducer polyinosine polycytidylic acid inhibited egress by a mechanism that was partly lymphocyte-intrinsic, and observations indicate that CD69 forms a complex with and negatively regulates S1P1 and that it functions downstream ofIFN- α/β, and possibly other activating stimuli, to promote lymphocyte retention in lymphoid organs.
Journal ArticleDOI
Lymphocyte Sequestration Through S1P Lyase Inhibition and Disruption of S1P Gradients
TL;DR: It is concluded that lymphocyte egress is mediated by S 1P gradients that are established by S1P lyase activity and that the lyase may represent a novel immunosuppressant drug target.
Journal ArticleDOI
A transmembrane CXC chemokine is a ligand for HIV-coreceptor Bonzo.
TL;DR: A protein with the hallmarks of a chemokine, designated CXCL16, that is made by dendritic cells in lymphoid organ T cell zones and by cells in the splenic red pulp is described, indicating roles in thymocyte development and effector T cell trafficking.