L
Lawrence R. Shiow
Researcher at University of California, San Francisco
Publications - 13
Citations - 2492
Lawrence R. Shiow is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Severe combined immunodeficiency & Wnt signaling pathway. The author has an hindex of 11, co-authored 13 publications receiving 2007 citations. Previous affiliations of Lawrence R. Shiow include University of California, Berkeley.
Papers
More filters
Journal ArticleDOI
CD69 acts downstream of interferon-alpha/beta to inhibit S1P1 and lymphocyte egress from lymphoid organs.
Lawrence R. Shiow,David B. Rosen,Naděžda Brdičková,Ying Xu,Jinping An,Lewis L. Lanier,Jason G. Cyster,Mehrdad Matloubian +7 more
TL;DR: Treatment with the IFN-α/β inducer polyinosine polycytidylic acid inhibited egress by a mechanism that was partly lymphocyte-intrinsic, and observations indicate that CD69 forms a complex with and negatively regulates S1P1 and that it functions downstream ofIFN- α/β, and possibly other activating stimuli, to promote lymphocyte retention in lymphoid organs.
Journal ArticleDOI
Neuronal vulnerability and multilineage diversity in multiple sclerosis
Lucas Schirmer,Dmitry Velmeshev,Staffan Holmqvist,Max Kaufmann,Sebastian Werneburg,Diane Jung,Stephanie Vistnes,John H. Stockley,Adam Young,Maike Steindel,Brian Tung,Brian Tung,Nitasha Goyal,Nitasha Goyal,Aparna Bhaduri,Simone Mayer,Jan Broder Engler,Omer Ali Bayraktar,Robin J.M. Franklin,Maximilian Haeussler,Richard Reynolds,Dorothy P. Schafer,Manuel A. Friese,Lawrence R. Shiow,Arnold R. Kriegstein,David H. Rowitch,David H. Rowitch +26 more
TL;DR: A map of gene expression in lesions from brains of patients with multiple sclerosis is constructed, revealing distinct lineage- and region-specific transcriptomic changes associated with selective cortical neuron damage and glial activation.
Journal ArticleDOI
CD69 Suppresses Sphingosine 1-Phosophate Receptor-1 (S1P1) Function through Interaction with Membrane Helix 4
TL;DR: It is suggested that CD69 induces an S1P1 conformation that shares some properties of the ligand-bound state, thereby facilitating S1F1 internalization and degradation, and identifying an integral membrane interaction between CD69 and S1p1.
Journal ArticleDOI
The actin regulator coronin 1A is mutant in a thymic egress-deficient mouse strain and in a patient with severe combined immunodeficiency.
Lawrence R. Shiow,David W. Roadcap,Kenneth Paris,Susan R. Watson,Irina L. Grigorova,Tonya Lebet,Jinping An,Ying Xu,Craig N. Jenne,Niko Föger,Ricardo U. Sorensen,Christopher C. Goodnow,James E. Bear,Jennifer M. Puck,Jason G. Cyster +14 more
TL;DR: A function for coronin 1A in T cell egress is established, a surface of coronin involved in Arp2/3 regulation is identified and actin regulation is a biological process defective in human and mouse severe combined immunodeficiency.
Journal ArticleDOI
Severe Combined Immunodeficiency (SCID) and Attention Deficit Hyperactivity Disorder (ADHD) Associated with a Coronin-1A Mutation and a Chromosome 16p11.2 Deletion
Lawrence R. Shiow,Kenneth Paris,Matthew Akana,Jason G. Cyster,Ricardo U. Sorensen,Jennifer M. Puck +5 more
TL;DR: This case highlights the first link between actin cytoskeleton regulation and SCID, and identifies absence of Coronin-1A in a girl with T-B+NK+ SCID who suffered recurrent infections including severe post-vaccination varicella at age 13 months.