M
Mei Xin
Researcher at Cincinnati Children's Hospital Medical Center
Publications - 42
Citations - 4671
Mei Xin is an academic researcher from Cincinnati Children's Hospital Medical Center. The author has contributed to research in topics: Medicine & Oligodendrocyte. The author has an hindex of 22, co-authored 32 publications receiving 3768 citations. Previous affiliations of Mei Xin include University of Texas at Dallas & University of Texas Southwestern Medical Center.
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Journal ArticleDOI
Hippo pathway effector Yap promotes cardiac regeneration
Mei Xin,Yuri Kim,Lillian B. Sutherland,Masao Murakami,Xiaoxia Qi,John McAnally,Enzo R. Porrello,Ahmed I. Mahmoud,Wei Tan,John M. Shelton,James A. Richardson,Hesham A. Sadek,Rhonda Bassel-Duby,Eric N. Olson +13 more
TL;DR: It is reported that mice bearing mutant alleles of Yap and its paralog WW domain containing transcription regulator 1 (Taz) exhibit gene dosage-dependent cardiac phenotypes, suggesting redundant roles of these Hippo pathway effectors in establishing proper myocyte number and maintaining cardiac function.
Journal ArticleDOI
MicroRNAs miR-143 and miR-145 modulate cytoskeletal dynamics and responsiveness of smooth muscle cells to injury.
Mei Xin,Eric M. Small,Lillian B. Sutherland,Xiaoxia Qi,John McAnally,Craig F. Plato,James A. Richardson,Rhonda Bassel-Duby,Eric N. Olson +8 more
TL;DR: MiR-143 and miR-145 act as integral components of the regulatory network whereby SRF controls cytoskeletal remodeling and phenotypic switching of SMCs during vascular disease.
Journal ArticleDOI
Regulation of Insulin-Like Growth Factor Signaling by Yap Governs Cardiomyocyte Proliferation and Embryonic Heart Size
Mei Xin,Yuri Kim,Lillian B. Sutherland,Xiaoxia Qi,John McAnally,Robert J. Schwartz,Robert J. Schwartz,James A. Richardson,Rhonda Bassel-Duby,Eric N. Olson +9 more
TL;DR: Yap is shown to be a critical downstream effector of the Hippo pathway in the control of cardiomyocyte proliferation and a nexus for coupling the IGF, Wnt, and Hippo signaling pathways with the developmental program for heart growth.
Journal ArticleDOI
Mending broken hearts: cardiac development as a basis for adult heart regeneration and repair
TL;DR: Stimulating cardiomyocyte dedifferentiation and proliferation by activating mitotic signalling pathways involved in embryonic heart growth represents a complementary approach for heart regeneration and repair.
Journal ArticleDOI
Functional screening in human cardiac organoids reveals a metabolic mechanism for cardiomyocyte cell cycle arrest
Richard J. Mills,Drew M. Titmarsh,Xaver Koenig,Xaver Koenig,Benjamin L. Parker,James G. Ryall,Gregory A. Quaife-Ryan,Holly K. Voges,Mark P. Hodson,Charles Ferguson,Lauren Drowley,Alleyn T. Plowright,Elise J. Needham,Qing-Dong Wang,Paul Gregorevic,Mei Xin,Walter G. Thomas,Robert G. Parton,Lars K. Nielsen,Bradley S. Launikonis,David E. James,David A. Elliott,Enzo R. Porrello,James E. Hudson +23 more
TL;DR: It is found that simulating the postnatal switch in metabolic substrates from carbohydrates to fatty acids promoted a switch in metabolism, DNA damage response, and cell cycle arrest in hPSC-CM, and under optimized maturation conditions, functional and molecular characterization revealed that a switch to fatty acid metabolism was a central driver of cardiac maturation.