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Robert J. Schwartz
Researcher at University of Houston
Publications - 249
Citations - 23644
Robert J. Schwartz is an academic researcher from University of Houston. The author has contributed to research in topics: Serum response factor & Regulation of gene expression. The author has an hindex of 81, co-authored 246 publications receiving 22502 citations. Previous affiliations of Robert J. Schwartz include Baylor College of Medicine & Texas A&M University System.
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Dysregulation of Cardiogenesis, Cardiac Conduction, and Cell Cycle in Mice Lacking miRNA-1-2
Yong Zhao,Joshua F. Ransom,Ankang Li,Ankang Li,Vasanth Vedantham,Morgan von Drehle,Alecia N. Muth,Takatoshi Tsuchihashi,Michael T. McManus,Robert J. Schwartz,Deepak Srivastava +10 more
TL;DR: It is shown that miRNA biogenesis in the mouse heart is essential for cardiogenesis, and targeted deletion of the muscle-specific miRNA, miR-1-2, revealed numerous functions in the heart, including regulation of cardiac morphogenesis, electrical conduction, and cell-cycle control.
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The cardiac transcription factors Nkx2-5 and GATA-4 are mutual cofactors
TL;DR: The tissue‐restricted GATA‐4 transcription factor and Nkx2‐5 homeodomain protein are two early markers of precardiac cells and the GATA/Nkx partnership may represent a paradigm for transcription factor interaction during organogenesis.
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Myogenic Vector Expression of Insulin-like Growth Factor I Stimulates Muscle Cell Differentiation and Myofiber Hypertrophy in Transgenic Mice *
Michael Coleman,Francesco J. DeMayo,Kuo Chang Yin,Heung Man Lee,Robert S. Geske,Chuck Montgomery,Robert J. Schwartz +6 more
TL;DR: Results indicate that sustained overexpression of IGF-I in skeletal muscle elicits myofiber hypertrophy and provides the basis for manipulation of muscle physiology utilizing skeletal α-actin-based vectors.
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MicroRNA regulation of cell lineages in mouse and human embryonic stem cells.
Kathryn N. Ivey,Alecia N. Muth,Joshua Arnold,Frank W. King,Ru Fang Yeh,Jason E. Fish,Edward C. Hsiao,Robert J. Schwartz,Bruce R. Conklin,Harold S. Bernstein,Deepak Srivastava +10 more
TL;DR: It is shown that two serum response factor (SRF)-dependent muscle-specific microRNAs, miR-1 andMiR-133, promote mesoderm formation from ES cells but have opposing functions during further differentiation into cardiac muscle progenitors.
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Thymosin beta4 induces adult epicardial progenitor mobilization and neovascularization.
Nicola Smart,Catherine A. Risebro,Athalie A. D. Melville,Kelvin A. Moses,Robert J. Schwartz,Kenneth R. Chien,Paul R. Riley +6 more
TL;DR: Thymosin β4 (Tβ4) is identified as essential for all aspects of coronary vessel development in mice, and it is demonstrated that Tβ4 stimulates significant outgrowth from quiescent adult epicardial explants, restoring pluripotency and triggering differentiation of fibroblasts, smooth muscle cells and endothelial cells.