M
Mel Lobo
Researcher at Barts Health NHS Trust
Publications - 20
Citations - 2516
Mel Lobo is an academic researcher from Barts Health NHS Trust. The author has contributed to research in topics: Medicine & Blood pressure. The author has an hindex of 4, co-authored 7 publications receiving 2344 citations.
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Journal ArticleDOI
Renal sympathetic denervation in patients with treatment-resistant hypertension (The Symplicity HTN-2 Trial): A randomised controlled trial
Murray D. Esler,Henry Krum,Paul A. Sobotka,Markus P. Schlaich,Roland E. Schmieder,Michael Böhm,Felix Mahfoud,Horst Sievert,Nina Wunderlich,Lars Christian Rump,Oliver Vonend,Michael Uder,Mel Lobo,Mark J. Caulfield,Andrejs Erglis,Michel Azizi,Marc Sapoval,S. Thambar,Alexandre Persu,Jean Renkin,Heribert Schunkert,Joachim Weil,Uta C. Hoppe,Tony Walton,Dierk Scheinert,Thomas Binder,Andrzej Januszewicz,Adam Witkowski,Luis M. Ruilope,Robert Whitbourn,Heike Bruck,Mark Downes,Thomas F. Lüscher,Alan G. Jardine,Mark Webster,Thomas Zeller,Jerzy Sadowski,Krzysztof Bartus,Craig A. Straley,Neil C. Barman,David P. Lee,Ronald M. Witteles,Vivek Bhalla,Joseph M. Massaro +43 more
TL;DR: Catheter-based renal denervation can safely be used to substantially reduce blood pressure in treatment-resistant hypertensive patients and should be continued, according to the authors.
Journal ArticleDOI
The Carotid Body as a Therapeutic Target for the Treatment of Sympathetically Mediated Diseases
Julian F. R. Paton,Paul A. Sobotka,Marat Fudim,Zoar J. Engelman,Emma C. Hart,Fiona D McBryde,Ana Paula Abdala,N Marina,Alexander V. Gourine,Mel Lobo,Nik Patel,Amy E Burchell,Laura E K Ratcliffe,Angus K Nightingale +13 more
TL;DR: In this article, the carotid body (CB) was targeted in patients with increased chemosensitivity to address the underlying autonomic imbalance seen in hypertension, heart failure, insulin resistance, and chronic kidney disorders.
Journal ArticleDOI
Guidance for the Interpretation of Continual Cuffless Blood Pressure Data for the Diagnosis and Management of Hypertension
Josep Solà,M. Cortés,David Perruchoud,Bastien De Marco,Mel Lobo,Cyril Pellaton,Grégoire Wuerzner,Naomi D.L. Fisher,Jay Shah +8 more
TL;DR: This guidance document aims to navigate the scientific and medical communities through the types of cuffless devices and present examples of robust BP data collection which are better representations of a person's true BP.
Journal ArticleDOI
Endovascular Ultrasound Renal Denervation to Treat Hypertension: The RADIANCE II Randomized Clinical Trial.
Michel Azizi,Manish Saxena,Yale Wang,J. Stephen Jenkins,Chandan Devireddy,Florian Rader,Naomi D.L. Fisher,Roland E. Schmieder,Felix Mahfoud,Jason B. Lindsey,Kintur Sanghvi,Thomas M. Todoran,John J. Pacella,John M. Flack,Joost Daemen,Andrew S.P. Sharp,Philipp Lurz,Michael J. Bloch,Michael A. Weber,Mel Lobo,Jan Basile,Lisa Claude,Helen Reeve-Stoffer,Candace K. McClure,Ajay J. Kirtane +24 more
TL;DR: In this paper , two initial sham-controlled trials demonstrated that ultrasound renal denervation decreases blood pressure (BP) in patients with mild to moderate hypertension and hypertension that is resistant to treatment.
Journal ArticleDOI
Clinical Trial Design Principles and Outcomes Definitions for Device-Based Therapies for Hypertension: A Consensus Document From the Hypertension Academic Research Consortium
David E. Kandzari,Felix Mahfoud,Michael A. Weber,Raymond R. Townsend,Gianfranco Parati,Naomi D.L. Fisher,Mel Lobo,Michael Bloch,Michael Böhm,Andrew S.P. Sharp,Roland E. Schmieder,Michel Azizi,Markus P. Schlaich,Vasilios Papademetriou,Ajay J. Kirtane,Joost Daemen,Atul Pathak,Christian Ukena,Philipp Lurz,Guido Grassi,Martin G. Myers,Aloke V. Finn,Marie-Claude Morice,Roxana Mehran,Peter Jüni,Gregg W. Stone,Mitchell W. Krucoff,Paul K. Whelton,Constantinos Tsioufis,Donald E. Cutlip,Ernest Spitzer +30 more
TL;DR: The HARC document integrates the collective information among device-based therapies for hypertension to better address existing challenges and identify unmet needs for technologies proposed to treat the world’s leading cause of death and disability.