M
Melania Capasso
Researcher at Queen Mary University of London
Publications - 38
Citations - 3237
Melania Capasso is an academic researcher from Queen Mary University of London. The author has contributed to research in topics: Immune system & Cytotoxic T cell. The author has an hindex of 16, co-authored 32 publications receiving 2587 citations. Previous affiliations of Melania Capasso include University of Leicester & German Center for Neurodegenerative Diseases.
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Journal ArticleDOI
The tumor microenvironment at a glance
TL;DR: Cancers are not just masses of malignant cells but complex ‘rogue’ organs, to which many other cells are recruited and can be corrupted by the transformed cells.
Journal ArticleDOI
Deregulated expression of cytokine receptor gene, CRLF2 , is involved in lymphoid transformation in B-cell precursor acute lymphoblastic leukemia
Lisa J. Russell,Melania Capasso,Inga Vater,Takashi Akasaka,Olivier Bernard,María José Calasanz,Thiruppavaii Chandrasekaran,Elise Chapiro,S Gesk,Mike Griffiths,David S. Guttery,Claudia Haferlach,Lana Harder,Olaf Heidenreich,Julie Irving,Lyndal Kearney,Florence Nguyen-Khac,Lee Machado,Lynne Minto,Aneela Majid,Anthony V. Moorman,Heather Morrison,Vikki Rand,Jonathan C. Strefford,Claire Schwab,Holger Tönnies,Martin J. S. Dyer,Reiner Siebert,Christine J. Harrison +28 more
TL;DR: Overexpression of CRLF2 was associated with activation of the JAK-STAT pathway in cell lines and transduced primary B-cell progenitors, sustaining their proliferation and indicating a causal role of C RLF2 overexpression in lymphoid transformation.
Journal ArticleDOI
HVCN1 modulates BCR signal strength via regulation of BCR-dependent generation of reactive oxygen species
Melania Capasso,Mandeep K Bhamrah,Tom Henley,Robert S. Boyd,Claudia Langlais,Kelvin Cain,David Dinsdale,Karen Pulford,Mahmood Khan,Boris Musset,Vladimir V. Cherny,Deri Morgan,Randy D. Gascoyne,Elena Vigorito,Thomas E. DeCoursey,Ian C. M. MacLennan,Martin J. S. Dyer +16 more
TL;DR: It is reported here that the voltage-gated proton channel HVCN1 associated with the BCR complex and was internalized together withThe BCR after activation, demonstrating the importance of ROS in BCR signaling and downstream metabolism.
Journal ArticleDOI
Voltage-gated proton channels maintain pH in human neutrophils during phagocytosis
Deri Morgan,Melania Capasso,Boris Musset,Vladimir V. Cherny,Eduardo Ríos,Martin J. S. Dyer,Thomas E. DeCoursey +6 more
TL;DR: Assessment of the pH changes accompanying phagocytosis in bone marrow phagocytes from HVCN1-deficient mice mirrored those in control mouse cells treated with Zn2+.
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A Strong B-cell Response Is Part of the Immune Landscape in Human High-Grade Serous Ovarian Metastases
Anne Montfort,Oliver M. T. Pearce,Eleni Maniati,Benjamin G. Vincent,Lisa M. Bixby,Steffen Böhm,Steffen Böhm,Thomas Dowe,Edmund Wilkes,Probir Chakravarty,Richard G. Thompson,Joanne Topping,Pedro R. Cutillas,Michelle Lockley,Michelle Lockley,Jonathan S. Serody,Melania Capasso,Frances R. Balkwill +17 more
TL;DR: In high-grade serous ovarian cancer (HGSOC), higher densities of both B cells and the CD8+ T-cell infiltrate were associated with a better prognosis but the precise role of B cells in the antitumor response remains unknown.