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Eleni Maniati
Researcher at Queen Mary University of London
Publications - 49
Citations - 1746
Eleni Maniati is an academic researcher from Queen Mary University of London. The author has contributed to research in topics: Tumor microenvironment & Medicine. The author has an hindex of 15, co-authored 34 publications receiving 1199 citations. Previous affiliations of Eleni Maniati include Imperial College London.
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Journal ArticleDOI
Nuclear FAK Controls Chemokine Transcription, Tregs, and Evasion of Anti-tumor Immunity
Alan Serrels,Tom Lund,Bryan Serrels,Adam Byron,Rhoanne C. McPherson,Alex von Kriegsheim,Laura Gómez-Cuadrado,Marta Canel,Morwenna Muir,Jennifer E. Ring,Eleni Maniati,Andrew H. Sims,Jonathan A. Pachter,Valerie G. Brunton,Nick Gilbert,Stephen M. Anderton,Robert J. B. Nibbs,Margaret C. Frame +17 more
TL;DR: Focal adhesion kinase inhibitors may trigger immune-mediated tumor regression, providing previously unrecognized therapeutic opportunities in cancerous squamous epithelial cells.
Journal ArticleDOI
Deconstruction of a Metastatic Tumor Microenvironment Reveals a Common Matrix Response in Human Cancers.
Oliver M. T. Pearce,Robin M. Delaine-Smith,Eleni Maniati,Sam Nichols,Jun Wang,Steffen Böhm,Vinothini Rajeeve,Dayem Ullah,Probir Chakravarty,Roanne R. Jones,Anne Montfort,Tom Dowe,John G. Gribben,J. Louise Jones,Hemant M. Kocher,Jonathan S. Serody,Benjamin G. Vincent,John T. Connelly,James D. Brenton,Claude Chelala,Pedro R. Cutillas,Michelle Lockley,Conrad Bessant,Martin M. Knight,Martin M. Knight,Frances R. Balkwill,Frances R. Balkwill +26 more
TL;DR: Although a single metastatic site from one human malignancy was studied, a pattern of expression of 22 matrisome genes distinguished patients with a shorter overall survival in ovarian and 12 other primary solid cancers, suggesting that there may be a common matrix response to human cancer.
Journal ArticleDOI
Crosstalk between the canonical NF-κB and Notch signaling pathways inhibits Pparγ expression and promotes pancreatic cancer progression in mice
Eleni Maniati,Maud Bossard,Natalie Cook,Juliana Candido,Nia Emami-Shahri,Sergei A. Nedospasov,Frances R. Balkwill,David A. Tuveson,Thorsten Hagemann +8 more
TL;DR: It is shown that inhibitor of κB kinase 2 (Ikk2), a component of the canonical NF-κB signaling pathway, synergizes with basal Notch signaling to upregulate transcription of primary Notch target genes, resulting in suppression of antiinflammatory protein expression and promotion of pancreatic carcinogenesis in mice
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A Strong B-cell Response Is Part of the Immune Landscape in Human High-Grade Serous Ovarian Metastases
Anne Montfort,Oliver M. T. Pearce,Eleni Maniati,Benjamin G. Vincent,Lisa M. Bixby,Steffen Böhm,Steffen Böhm,Thomas Dowe,Edmund Wilkes,Probir Chakravarty,Richard G. Thompson,Joanne Topping,Pedro R. Cutillas,Michelle Lockley,Michelle Lockley,Jonathan S. Serody,Melania Capasso,Frances R. Balkwill +17 more
TL;DR: In high-grade serous ovarian cancer (HGSOC), higher densities of both B cells and the CD8+ T-cell infiltrate were associated with a better prognosis but the precise role of B cells in the antitumor response remains unknown.
Journal ArticleDOI
Up for Mischief? IL-17/Th17 in the tumour microenvironment
TL;DR: The role of interleukin (IL)-17 and the IL-17-producing T helper (Th)17 cells in cancer has recently become the focus of extensive investigation and the reciprocal interactions between Th17 cells and other cells of the immune system are outlined.