M
Melanie N. Shackett
Researcher at Biogen Idec
Publications - 3
Citations - 454
Melanie N. Shackett is an academic researcher from Biogen Idec. The author has contributed to research in topics: Notch signaling pathway & In vivo. The author has an hindex of 3, co-authored 3 publications receiving 408 citations.
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Journal ArticleDOI
Fumarates Promote Cytoprotection of Central Nervous System Cells against Oxidative Stress via the Nuclear Factor (Erythroid-Derived 2)-Like 2 Pathway
Robert H. Scannevin,Sowmya Chollate,Mi Young Jung,Melanie N. Shackett,Hiral Patel,Pradeep Bista,Weike Zeng,Sarah Ryan,Masayuki Yamamoto,Matvey E. Lukashev,Kenneth J. Rhodes +10 more
TL;DR: DMF and MMF are cytoprotective for neurons and astrocytes against oxidative stress-induced cellular injury and loss, potentially via up-regulation of an Nrf2-dependent antioxidant response, and these data suggest DMF andMMF may function through improving mitochondrial function.
Journal ArticleDOI
Discovery of BIIB042, a Potent, Selective, and Orally Bioavailable γ-Secretase Modulator.
Hairuo Peng,Tina Talreja,Zhili Xin,J. Hernan Cuervo,Gnanasambandam Kumaravel,Michael Humora,Lin Xu,Ellen Rohde,Lawrence Gan,Mi-young Jung,Melanie N. Shackett,Sowmya Chollate,Anthone W. Dunah,Pamela A. Snodgrass-Belt,H. Moore Arnold,Arthur G. Taveras,Kenneth J. Rhodes,Robert H. Scannevin +17 more
TL;DR: Compound 10a is a potent γ-secretase modulator, which lowered Aβ42, increased Aβ38, but had little to no effect on Aβ40 levels both in vitro and in vivo, and demonstrated excellent pharmacokinetic parameters in multiple species.
Journal ArticleDOI
Discovery of 4-aminomethylphenylacetic acids as γ-secretase modulators via a scaffold design approach.
Zhili Xin,Hairuo Peng,Andrew Zhang,Tina Talreja,Gnanasambandam Kumaravel,Lin Xu,Ellen Rohde,Mi-yong Jung,Melanie N. Shackett,David Kocisko,Sowmya Chollate,Anthone W. Dunah,Pamela A. Snodgrass-Belt,H. Moore Arnold,Arthur G. Taveras,Kenneth J. Rhodes,Robert H. Scannevin +16 more
TL;DR: Starting from literature examples of nonsteroidal anti-inflammatory drugs (NSAIDs)-type carboxylic acid γ-secretase modulators (GSMs) and using a scaffold design approach, the discovery of a novel chemical series, represented by 6b, having improved brain penetration, is made.