M
Melanie P. Muller
Researcher at University of Illinois at Urbana–Champaign
Publications - 6
Citations - 261
Melanie P. Muller is an academic researcher from University of Illinois at Urbana–Champaign. The author has contributed to research in topics: Biological membrane & Membrane. The author has an hindex of 5, co-authored 5 publications receiving 179 citations. Previous affiliations of Melanie P. Muller include University of Illinois at Chicago.
Papers
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Journal ArticleDOI
Characterization of Lipid-Protein Interactions and Lipid-Mediated Modulation of Membrane Protein Function through Molecular Simulation.
Melanie P. Muller,Melanie P. Muller,Tao Jiang,Chang Sun,Muyun Lihan,Shashank Pant,Paween Mahinthichaichan,Anda Trifan,Emad Tajkhorshid +8 more
TL;DR: A broad survey of MD simulations focusing on exploring lipid-protein interactions and characterizing lipid-modulated protein structure and dynamics that have been successful in providing novel insight into the mechanism of membrane protein function is provided.
Journal ArticleDOI
Atomic-level description of protein-lipid interactions using an accelerated membrane model.
Javier L. Baylon,Josh V. Vermaas,Melanie P. Muller,Mark J. Arcario,Taras V. Pogorelov,Emad Tajkhorshid +5 more
TL;DR: In the highly mobile membrane-mimetic (HMMM) model the membrane core is replaced by an organic solvent, while short-tailed lipids provide a nearly complete representation of natural lipids at the organic solvent/water interface.
Journal ArticleDOI
Efficient Exploration of Membrane-Associated Phenomena at Atomic Resolution
Josh V. Vermaas,Javier L. Baylon,Mark J. Arcario,Melanie P. Muller,Zhe Wu,Taras V. Pogorelov,Emad Tajkhorshid +6 more
TL;DR: Successful application of the highly mobile membrane mimetic model to study a variety of membrane processes, including lipid-dependent binding and insertion of peripheral proteins, the mechanism of phospholipid insertion into lipid bilayers, and characterization of optimal tilt angle of transmembrane helices are described.
Journal ArticleDOI
Lipid specificity of the membrane binding domain of coagulation factor X.
TL;DR: Molecular dynamics simulations were used to develop the first membrane‐bound model of FX‐GLA, and potential PS‐specific binding sites identified.
Book ChapterDOI
Microscopic Characterization of Membrane Transporter Function by In Silico Modeling and Simulation.
Josh V. Vermaas,Noah Trebesch,Christopher G. Mayne,Sundarapandian Thangapandian,Mrinal Shekhar,Paween Mahinthichaichan,Javier Baylon,Tao Jiang,Yuhang Wang,Melanie P. Muller,Eric Shinn,Zhiyu Zhao,Po-Chao Wen,Emad Tajkhorshid +13 more
TL;DR: An overview of a number of major computational protocols and techniques commonly used in membrane transporter modeling and simulation studies is provided, including practical hints on effective use, critical perspectives on their strengths and weak points, and examples of their successful applications to membrane transporters.