M
Melinda D. Hains
Researcher at University of North Carolina at Chapel Hill
Publications - 9
Citations - 798
Melinda D. Hains is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: G protein-coupled receptor & RGS Proteins. The author has an hindex of 9, co-authored 9 publications receiving 753 citations.
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Journal ArticleDOI
G-protein signaling: back to the future
Christopher R. McCudden,Melinda D. Hains,Randall J. Kimple,David P. Siderovski,Francis S. Willard +4 more
TL;DR: In this paper, the authors revisited classical heterotrimeric G-protein signaling and explored these new, non-canonical Gprotein signaling pathways, including a receptor-independent Gα nucleotide cycle that regulates cell division.
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Guanine nucleotide dissociation inhibitor activity of the triple GoLoco motif protein G18: alanine-to-aspartate mutation restores function to an inactive second GoLoco motif
Randall J. Kimple,Francis S. Willard,Melinda D. Hains,Miller B. Jones,Gift K Nweke,David P. Siderovski +5 more
TL;DR: Cloned and expressed the G18 protein and assessed its ability to act as a GDI, finding that G18 is capable of simultaneously binding more than one Galpha(i1) subunit and exhibiting GDI activity.
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Gα12/13- and Rho-Dependent Activation of Phospholipase C-ϵ by Lysophosphatidic Acid and Thrombin Receptors
TL;DR: These studies illustrate that specific LPA and thrombin receptors promote inositol lipid signaling via activation of Gα12/13 and Rho.
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RGS12 Interacts with the SNARE-binding Region of the Cav2.2 Calcium Channel
Ryan W. Richman,Jesse Strock,Melinda D. Hains,Nory Jun Cabanilla,King Kei Lau,David P. Siderovski,María A. Diversé-Pierluissi +6 more
TL;DR: It is reported that RGS12 binds to the SNARE-binding or “synprint” region (amino acids 726-985) in loop II-III of the calcium channel α1 subunit, which is also important for determining the time course of the modulation of calcium current via tyrosine phosphorylation.
Journal ArticleDOI
The effect of RGS12 on PDGFβ receptor signalling to p42/p44 mitogen activated protein kinase in mammalian cells
Balwinder Sambi,Melinda D. Hains,Catherine M. Waters,Michelle Connell,Francis S. Willard,Adam J. Kimple,Susan Pyne,David P. Siderovski,Nigel J. Pyne +8 more
TL;DR: The results presented here provide the first evidence to support the concept that the PDZ/PTB domain N-terminus and/or the PTB domain of RGS12 may modulate PDGFbeta receptor signalling.