M
Melissa J. Cudmore
Researcher at University of Edinburgh
Publications - 22
Citations - 1977
Melissa J. Cudmore is an academic researcher from University of Edinburgh. The author has contributed to research in topics: Angiogenesis & Vascular endothelial growth factor A. The author has an hindex of 19, co-authored 22 publications receiving 1779 citations. Previous affiliations of Melissa J. Cudmore include University of Birmingham & British Heart Foundation.
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Journal ArticleDOI
Negative Regulation of Soluble Flt-1 and Soluble Endoglin Release by Heme Oxygenase-1
Melissa J. Cudmore,Shakil Ahmad,Bahjat Al-Ani,Takeshi Fujisawa,Heather Coxall,Kunal Chudasama,Luke Devey,Stephen J. Wigmore,Allyah Abbas,Peter W. Hewett,Asif Ahmed +10 more
TL;DR: It is demonstrated that the HO-1/CO pathway inhibits sFlt-1 and sEng release, providing compelling evidence for a protective role ofHO-1 in pregnancy, and identifies HO- 1 as a novel target for the treatment of preeclampsia.
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Dysregulation of Hydrogen Sulfide Producing Enzyme Cystathionine γ-lyase Contributes to Maternal Hypertension and Placental Abnormalities in Preeclampsia
Keqing Wang,Shakil Ahmad,Meng Cai,Jillian Rennie,Takeshi Fujisawa,Fatima Crispi,James Baily,Mark R. Miller,Melissa J. Cudmore,Patrick W. F. Hadoke,Rui Wang,Eduard Gratacós,Irina A. Buhimschi,Catalin S. Buhimschi,Asif Ahmed +14 more
TL;DR: Results imply that endogenous H2S is required for healthy placental vasculature and that a decrease in CSE/H2S activity may contribute to the pathogenesis of preeclampsia.
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Reduction of circulating soluble Flt-1 alleviates preeclampsia-like symptoms in a mouse model
Astrid Bergmann,Shakil Ahmad,Melissa J. Cudmore,Achim D. Gruber,Petra Wittschen,Werner Lindenmaier,Gerhard Christofori,Volkmar Gross,Andrey Ch. da Costa Gonzalves,Hermann Josef Gröne,Asif Ahmed,Herbert A. Weich +11 more
TL;DR: It is demonstrated that below a critical threshold sFlt‐1 fails to elicit damage to the fenestrated endothelium and that co‐expression of VEGF is able to rescue effects mediated by sFolt‐1 overexpression.
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VEGF Induces Tie2 Shedding via a Phosphoinositide 3-Kinase/Akt–Dependent Pathway to Modulate Tie2 Signaling
TL;DR: These findings demonstrate that VEGF regulates angiopoietin-Tie2 signaling by inducing proteolytic cleavage and shedding of Tie2 via a novel PI3K/Akt-dependent pathway, and suggest a previously unrecognized mechanism by which V EGF may inhibit vascular stabilization to promote angiogenesis and vascular remodeling.
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Flt1 acts as a negative regulator of tip cell formation and branching morphogenesis in the zebrafish embryo.
Janna Krueger,Dong Liu,Katja Scholz,Anja Zimmer,Yu Shi,Christian Klein,Arndt F. Siekmann,Stefan Schulte-Merker,Melissa J. Cudmore,Asif Ahmed,Ferdinand le Noble +10 more
TL;DR: Flt1 acts in a Notch-dependent manner as a negative regulator of tip cell differentiation and branching in zebrafish, involving interactions with the developing nervous system.