M
Melissa L. Madsen
Researcher at Iowa State University
Publications - 12
Citations - 700
Melissa L. Madsen is an academic researcher from Iowa State University. The author has contributed to research in topics: Mycoplasma hyopneumoniae & Gene. The author has an hindex of 10, co-authored 12 publications receiving 657 citations.
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Journal ArticleDOI
The Genome Sequence of Mycoplasma hyopneumoniae Strain 232, the Agent of Swine Mycoplasmosis
F. Chris Minion,Elliot J. Lefkowitz,Melissa L. Madsen,Barbara J. Cleary,Steven Swartzell,Gregory G. Mahairas +5 more
TL;DR: The complete genome sequence of Mycoplasma hyopneumoniae, an important member of the porcine respiratory disease complex, is presented, finding few genes with tandem repeat sequences that could be involved in phase switching or antigenic variation and it is not clear how M. hyop pneumoniae evades the immune response and establishes a chronic infection.
Journal ArticleDOI
Real-Time PCR Assays To Address Genetic Diversity among Strains of Mycoplasma hyopneumoniae
Erin L. Strait,Melissa L. Madsen,F. Chris Minion,Jane Christopher-Hennings,Matthew A. Dammen,Katherine R. Jones,Eileen L. Thacker +6 more
TL;DR: Two new real-time PCR assays that are specific and capable of detecting all of the M. hyopneumoniae isolates used in this study were developed were developed.
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Transcriptional profiling of Mycoplasma hyopneumoniae during heat shock using microarrays
TL;DR: 91 genes that had significant transcriptional differences in response to heat shock conditions were identified and many of the heat shock proteins previously characterized in other bacteria were identified as significant in this study as well.
Journal ArticleDOI
Global transcriptional analysis of Mycoplasma hyopneumoniae following exposure to norepinephrine.
TL;DR: In response to norepinephrine, M. hyopneumoniae appears to upregulate protein expression while downregulating general metabolism, which correlated with the reduction in growth of the mycoplasma.
Journal ArticleDOI
Transcriptome Changes in Mycoplasma hyopneumoniae during Infection
Melissa L. Madsen,Supraja Puttamreddy,Eileen L. Thacker,Michael D. Carruthers,F. Chris Minion +4 more
TL;DR: During lung infection, the analysis indicated that 79 M. hyopneumoniae genes were differentially expressed, and 28 of 46 lacked an assigned function, in comparison to 21 of 33 (63%) of up-regulated genes.