M
Melissa Phillips
Researcher at Barts Health NHS Trust
Publications - 21
Citations - 729
Melissa Phillips is an academic researcher from Barts Health NHS Trust. The author has contributed to research in topics: Argininosuccinate synthase & Pemetrexed. The author has an hindex of 7, co-authored 15 publications receiving 502 citations. Previous affiliations of Melissa Phillips include Queen Mary University of London & St Bartholomew's Hospital.
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Journal ArticleDOI
Capivasertib Plus Paclitaxel Versus Placebo Plus Paclitaxel As First-Line Therapy for Metastatic Triple-Negative Breast Cancer: The PAKT Trial.
Peter Schmid,Jacinta Abraham,Stephen Chan,Duncan Wheatley,A.M. Brunt,Gia Nemsadze,Richard D. Baird,Yeon Hee Park,Peter Hall,Timothy J. Perren,Robert Stein,László Mangel,Jean-Marc Ferrero,Melissa Phillips,John Conibear,Javier Cortes,Andrew Foxley,Elza C. de Bruin,Robert McEwen,Daniel Stetson,Brian Dougherty,Shah-Jalal Sarker,Aaron Prendergast,Max McLaughlin-Callan,Matthew Burgess,Cheryl Lawrence,Hayley Cartwright,Kelly Mousa,Nicholas C. Turner,Nicholas C. Turner +29 more
TL;DR: Addition of the AKT inhibitor capivasertib to first-line paclitaxel therapy for TNBC resulted in significantly longer PFS and OS, and benefits were more pronounced in patients with PIK3CA/AKT1/PTEN-altered tumors.
Journal ArticleDOI
Targeting arginine-dependent cancers with arginine-degrading enzymes: opportunities and challenges.
TL;DR: The challenge will be to identify tumors sensitive to drugs such as ADI-PEG20 and integrate these agents into multimodality drug regimens using imaging and tissue/fluid-based biomarkers as predictors of response.
Journal ArticleDOI
Arginine Deprivation With Pegylated Arginine Deiminase in Patients With Argininosuccinate Synthetase 1-Deficient Malignant Pleural Mesothelioma: A Randomized Clinical Trial.
Peter W. Szlosarek,Peter W. Szlosarek,Jeremy P.C. Steele,Luke Nolan,David Gilligan,Paul Taylor,James Spicer,Michael J. Lind,Sankhasuvra Mitra,Jonathan Shamash,Melissa Phillips,Melissa Phillips,Phuong Luong,Sarah Payne,Paul Hillman,Stephen Ellis,Teresa Szyszko,Gairin Dancey,Lee M. Butcher,Stephan Beck,Norbert Avril,Jim Thomson,Amanda Johnston,Marianne Tomsa,Cheryl Lawrence,Peter Schmid,Peter Schmid,Tim Crook,Bor Wen Wu,John S. Bomalaski,Nicholas R. Lemoine,Michael Sheaff,Robin M. Rudd,D.A. Fennell,Allan Hackshaw +34 more
TL;DR: In this trial, arginine deprivation with ADI-PEG20 improved PFS in patients with ASS1-deficient malignant pleural mesothelioma and warrants further clinical investigation inArginine-dependent cancers.
Journal ArticleDOI
Metabolic Response to Pegylated Arginine Deiminase in Mesothelioma With Promoter Methylation of Argininosuccinate Synthetase
Peter W. Szlosarek,Phuong Luong,Melissa Phillips,Marina Baccarini,Stephen Ellis,Teresa Szyszko,Michael Sheaff,Norbert Avril +7 more
Journal ArticleDOI
AZD5363 plus paclitaxel versus placebo plus paclitaxel as first-line therapy for metastatic triple-negative breast cancer (PAKT): A randomised, double-blind, placebo-controlled, phase II trial.
Peter Schmid,Jacinta Abraham,Stephen Chan,Duncan Wheatley,Murray Brunt,Gia Nemsadze,Richard D. Baird,Yeon Hee Park,Peter Hall,Timothy J. Perren,Robert Stein,Mangel László,Jean-Marc Ferrero,Melissa Phillips,John Conibear,Shah-Jalal Sarker,Aaron Prendergast,Hayley Cartwright,Kelly Mousa,Nicholas C. Turner +19 more
TL;DR: The PAKT trial investigated the addition of AZD5363 to paclitaxel as 1st-line therapy for TNBC by randomising women with previously untreated, metastatic TNBC to this highly-selective, oral, small molecule AKT inhibitor.