A
Allan Hackshaw
Researcher at University College London
Publications - 187
Citations - 10928
Allan Hackshaw is an academic researcher from University College London. The author has contributed to research in topics: Medicine & Lung cancer. The author has an hindex of 43, co-authored 143 publications receiving 8676 citations. Previous affiliations of Allan Hackshaw include London Research Institute & Cancer Research UK.
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Journal ArticleDOI
Tracking the Evolution of Non–Small-Cell Lung Cancer
Mariam Jamal-Hanjani,Gareth A. Wilson,Nicholas McGranahan,Nicolai Juul Birkbak,Thomas B.K. Watkins,Selvaraju Veeriah,Seema Shafi,Diana Johnson,Richard Mitter,Rachel Rosenthal,Max Salm,Stuart Horswell,Mickael Escudero,Nik Matthews,Andrew Rowan,Tim Chambers,David A. Moore,Samra Turajlic,Hang Xu,Siow Ming Lee,Martin Forster,Tanya Ahmad,Crispin T. Hiley,Christopher Abbosh,Mary Falzon,Elaine Borg,Teresa Marafioti,David Lawrence,Martin Hayward,Shyam Kolvekar,Nikolaos Panagiotopoulos,Sam M. Janes,Ricky Thakrar,Asia Ahmed,Fiona H Blackhall,Yvonne Summers,Rajesh Shah,Leena Dennis Joseph,Anne Marie Quinn,Phil Crosbie,Babu Naidu,Gary Middleton,Gerald Langman,Simon Trotter,Marianne Nicolson,Hardy Remmen,Keith Kerr,Mahendran Chetty,Lesley Gomersall,Dean A. Fennell,Apostolos Nakas,Sridhar Rathinam,Girija Anand,Sajid A. Khan,Peter Russell,Veni Ezhil,Babikir Ismail,Melanie Irvin-Sellers,Vineet Prakash,Jason F. Lester,Malgorzata Kornaszewska,Richard Attanoos,Haydn Adams,Helen Davies,Stefan C. Dentro,Philippe Taniere,Brendan O'Sullivan,Helen Lowe,John A. Hartley,Natasha Iles,Harriet Bell,Yenting Ngai,Jacqui Shaw,Javier Herrero,Zoltan Szallasi,Roland F. Schwarz,Aengus Stewart,Sergio A. Quezada,John Le Quesne,Peter Van Loo,Caroline Dive,Allan Hackshaw,Charles Swanton +82 more
TL;DR: Intratumor heterogeneity mediated through chromosome instability was associated with an increased risk of recurrence or death, a finding that supports the potential value of chromosome instability as a prognostic predictor.
Journal ArticleDOI
Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution
Christopher Abbosh,Nicolai Juul Birkbak,Nicolai Juul Birkbak,Gareth A. Wilson,Gareth A. Wilson,Mariam Jamal-Hanjani,Tudor Constantin,Raheleh Salari,John Le Quesne,David A. Moore,Selvaraju Veeriah,Rachel Rosenthal,Teresa Marafioti,Eser Kirkizlar,Thomas B.K. Watkins,Thomas B.K. Watkins,Nicholas McGranahan,Nicholas McGranahan,Sophia Ward,Sophia Ward,Luke Martinson,Joan Riley,Francesco Fraioli,Maise Al Bakir,Eva Grönroos,Francisco Zambrana,Raymondo Endozo,Wenya Linda Bi,Wenya Linda Bi,Fiona M. Fennessy,Fiona M. Fennessy,Nicole Sponer,Diana Johnson,Joanne Laycock,Seema Shafi,Justyna Czyzewska-Khan,Andrew Rowan,Tim Chambers,Nik Matthews,Nik Matthews,Samra Turajlic,Samra Turajlic,Crispin T. Hiley,Crispin T. Hiley,Siow Ming Lee,Martin Forster,Tanya Ahmad,Mary Falzon,Elaine Borg,David Lawrence,Martin Hayward,Shyam Kolvekar,Nikolaos Panagiotopoulos,Sam M. Janes,Ricky Thakrar,Asia Ahmed,Fiona H Blackhall,Yvonne Summers,Dina Hafez,Ashwini Naik,Apratim Ganguly,Stephanie Kareht,Rajesh Shah,Leena Dennis Joseph,Anne Marie Quinn,Phil Crosbie,Babu Naidu,Gary Middleton,Gerald Langman,Simon Trotter,Marianne Nicolson,Hardy Remmen,Keith M. Kerr,Mahendran Chetty,Lesley Gomersall,Dean A. Fennell,Apostolos Nakas,Sridhar Rathinam,Girija Anand,Sajid Khan,Peter Russell,Veni Ezhil,Babikir Ismail,Melanie Irvin-Sellers,Vineet Prakash,Jason F. Lester,Malgorzata Kornaszewska,Richard Attanoos,Haydn Adams,Helen E. Davies,Dahmane Oukrif,Ayse U. Akarca,John A. Hartley,Helen Lowe,Sara Lock,Natasha Iles,Harriet Bell,Yenting Ngai,Greg Elgar,Zoltan Szallasi,Zoltan Szallasi,Zoltan Szallasi,Roland F. Schwarz,Javier Herrero,Aengus Stewart,Sergio A. Quezada,Karl S. Peggs,Peter Van Loo,Peter Van Loo,Caroline Dive,Caroline Dive,C. Jimmy Lin,Matthew Rabinowitz,Hugo J.W.L. Aerts,Hugo J.W.L. Aerts,Allan Hackshaw,Jacqui Shaw,Bernhard Zimmermann,Charles Swanton,Charles Swanton +119 more
TL;DR: It is shown that phylogenetic ct DNA profiling tracks the subclonal nature of lung cancer relapse and metastasis, providing a new approach for ctDNA-driven therapeutic studies.
Journal ArticleDOI
First and second trimester antenatal screening for Down's syndrome: the results of the Serum, Urine and Ultrasound Screening Study (SURUSS).
TL;DR: The matching criteria were gestation (using an ultrasound crown–rump length or biparietal diameter measurement), duration of storage, and centre, and Screening performance of the individual markers and combinations of markers together with maternal age was assessed.
Journal ArticleDOI
Maternal smoking in pregnancy and birth defects: a systematic review based on 173 687 malformed cases and 11.7 million controls
TL;DR: Birth defects that are positively associated with maternal smoking should now be included in public health educational materials to encourage more women to quit before or during pregnancy.
Journal ArticleDOI
Ablation with Low-Dose Radioiodine and Thyrotropin Alfa in Thyroid Cancer
Ujjal Mallick,Clive Harmer,Beng K. Yap,Jonathan Wadsley,Susan E. M. Clarke,Laura Moss,Alice Nicol,Penelope M. Clark,Kate Farnell,Ralph V McCready,James Smellie,J. A. Franklyn,Rhys John,Christopher M. Nutting,Kate Newbold,Catherine Lemon,Georgina Gerrard,Abdel Abdel-Hamid,John Hardman,Elena Macias,Tom Roques,Stephen Whitaker,Rengarajan Vijayan,Pablo Alvarez,Sandy Beare,Sharon Forsyth,Latha Kadalayil,Allan Hackshaw +27 more
TL;DR: Low-dose radioiodine plus thyrotropin alfa was as effective as high-doseRadioiodine, with a lower rate of adverse events, in a randomized noninferiority trial of patients with differentiated thyroid cancer.