M
Meng-Liang Zhao
Researcher at Albert Einstein College of Medicine
Publications - 7
Citations - 1015
Meng-Liang Zhao is an academic researcher from Albert Einstein College of Medicine. The author has contributed to research in topics: Microglia & Neuroglia. The author has an hindex of 7, co-authored 7 publications receiving 928 citations.
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Journal ArticleDOI
Expression of the translocator protein of 18 kDa by microglia, macrophages and astrocytes based on immunohistochemical localization in abnormal human brain.
Melissa Cosenza-Nashat,Meng-Liang Zhao,Hyeon-Sook Suh,Janet Morgan,Ryan Natividad,Susan Morgello,Sunhee C. Lee +6 more
TL;DR: The first comprehensive immunohistochemical analysis of the expression of TSPO is provided, useful for informing the usage of positron emission tomography as an imaging modality and have an impact on the potential use of T SPO as an anti‐inflammatory pharmacological target.
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Expression of Inducible Nitric Oxide Synthase and Nitrotyrosine in Multiple Sclerosis Lesions
TL;DR: The conclusion that iNOS is induced in multiple cell types in MS lesions and that astrocyte-derived nitric oxide could be important in orchestrating inflammatory responses in MS, particularly at the blood-brain barrier is supported.
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Expression of inducible nitric oxide synthase, interleukin-1 and caspase-1 in HIV-1 encephalitis
TL;DR: Results support the notion that autocrine and paracrine interactions between HIV-1 infected macrophages and microglia, activated micro glia, and astrocytes lead to expression of proinflammatory and neurotoxic molecules.
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TLR3 and TLR4 are innate antiviral immune receptors in human microglia: role of IRF3 in modulating antiviral and inflammatory response in the CNS.
TL;DR: Results indicate that activation of TLR3 or TLR4 will elicit antiviral immunity, in addition to inducing proinflammatory responses, and suggest that a balanced expression between inflammatory and innate immune genes might be achieved by IRF3 over-expression.
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HIV-1 expression protects macrophages and microglia from apoptotic death
TL;DR: The results suggest that HIV‐1‐infected macrophages and microglia are resistant to apoptosis, and may contribute to the formation of a central nervous system viral reservoir.