Meng Qiao

TL;DR: This work demonstrated that low-dose apatinib alleviated hypoxia, increased infiltration of CD8+ T cells, reduced recruitment of tumor-associated macrophages in tumor and decreased TGFβ amounts in both tumor and serum, which shows the rationale for the treatment of lung cancer with a combination of PD-1/PD-L1 blockade and low- dose apatinIB.

TL;DR: In this paper, the authors analyzed 42 tissue biopsy samples from stage III/IV NSCLC patients by single cell RNA sequencing and presented the large scale, single cell resolution profiles of advanced NSCLCs.

TL;DR: This study systematically analyzed dynamic changes in tumor microenvironments responding to EGFR‐TKIs in vivo and found the optimal sequence of the treatment and strategies that modulate the tumor microenvironment to a state that may favor antitumor immune responses need to be considered when designing clinical trials.

TL;DR: High CD73 expression was significantly associated with lymph node metastases and a promising prognostic factor in different types of cancers.

TL;DR: The cutting-edge progress made in patients with lung cancer, the optimal duration of ICI treatment, ICIs in some special populations, the unique response patterns during ICItreatment, the emerging predictive biomarkers, and the understanding of primary and acquired resistance mechanisms to ICI Treatment are described are described.