M
Menglan Xiang
Researcher at Stanford University
Publications - 12
Citations - 203
Menglan Xiang is an academic researcher from Stanford University. The author has contributed to research in topics: Lymphatic system & Lymph node. The author has an hindex of 6, co-authored 9 publications receiving 133 citations. Previous affiliations of Menglan Xiang include University of North Dakota & Veterans Health Administration.
Papers
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Journal ArticleDOI
A Single-Cell Transcriptional Roadmap of the Mouse and Human Lymph Node Lymphatic Vasculature.
Menglan Xiang,Menglan Xiang,Rubén Adrián Grosso,Akira Takeda,Junliang Pan,Tove Bekkhus,Kevin Brulois,Denis Dermadi,Sofia Nordling,Sofia Nordling,Michael Vanlandewijck,Michael Vanlandewijck,Sirpa Jalkanen,Maria H. Ulvmar,Eugene C. Butcher,Eugene C. Butcher +15 more
TL;DR: In this paper, a single-cell analysis of mouse lymph node (LN) lymphatic endothelial cells (LEC) at singlecell resolution is presented, which reveals a conserved cross-species pattern of lymphatic vascular niches and gene expression, as well as specialized human subsets and genes unique to each species.
Journal ArticleDOI
Gata4 potentiates second heart field proliferation and Hedgehog signaling for cardiac septation
Lun Zhou,Jielin Liu,Menglan Xiang,Patrick Olson,Alexander Guzzetta,Ke Zhang,Ivan P. Moskowitz,Linglin Xie +7 more
TL;DR: Both the cell-cycle and Hh-signaling defects caused by dominant Gata4 mutations were required for CHD pathogenesis, suggesting a combinatorial model of disease causation by transcription factor haploinsufficiency.
Journal ArticleDOI
Gene-network and familial analyses uncover a gene network involving Tbx5/Osr1/Pcsk6 interaction in the second heart field for atrial septation
Ke Zhang,Menglan Xiang,Lun Zhou,Jielin Liu,Nathan Curry,Damian Heine Suñer,Pablo Garcia-Pavia,Xiaohua Zhang,Qin Wang,Qin Wang,Linglin Xie +10 more
TL;DR: This study implicated a gene network involving Tbx5, Osr1 and Pcsk6 interaction in SHF for atrial septation, providing a molecular framework for understanding the role of T bx5 in CHD ontogeny.
Journal ArticleDOI
Endothelial HIF-2α as a Key Endogenous Mediator Preventing Emphysema.
Shravani Pasupneti,Shravani Pasupneti,Wen Tian,Wen Tian,Allen B. Tu,Allen B. Tu,Petra Dahms,Petra Dahms,Eric J. Granucci,Eric J. Granucci,Aneta Gandjeva,Menglan Xiang,Menglan Xiang,Eugene C. Butcher,Eugene C. Butcher,Gregg L. Semenza,Rubin M. Tuder,Xinguo Jiang,Xinguo Jiang,Mark R. Nicolls,Mark R. Nicolls +20 more
TL;DR: A unique, protective role is demonstrated for pulmonary endothelial HIF-2α and how decreased expression of this endogenous factor causes emphysema is demonstrated; its pivotal protective function is suggested by its ability to overcome VEGF antagonism.
Journal ArticleDOI
Gata4 regulates hedgehog signaling and Gata6 expression for outflow tract development
Jielin Liu,Jielin Liu,Henghui Cheng,Henghui Cheng,Menglan Xiang,Lun Zhou,Lun Zhou,Bingruo Wu,Ivan P. Moskowitz,Ke Zhang,Linglin Xie,Linglin Xie +11 more
TL;DR: In this paper, Gata4-responsive repressive sites were identified within 1kbp upstream of the transcription start site of Gata6 by both ChIP-qPCR and luciferase reporter assay.