Mengyi Ye

TL;DR: The X-ray structure of NS5 presented here suggests thatMTase and RdRp activities could be coordinated as a dimer during viral genome replication, providing evidence that flavivirus NS5 can adopt multiple conformations while preserving necessary interactions between the MTase and RoadRp domains.

TL;DR: The zinc-binding ability of N(pro), the first protein encoded by the single large open reading frame of the pestivirus positive-sense RNA genome, appears to be essential for the virus-mediated degradation of IRF3.

TL;DR: The abilities of four polymerases (3D(pol), from EV-species A-C, to uridylylate VPgs that varied by up to 60% of their residues were compared, and the conservation of polymerase residues whose mutation reduces uridyglylation but not RNA elongation is compared.

TL;DR: Fundamental aspects of interactions of the Dengue virus type 3 full-length polymerase with the single-stranded and double- Stranded RNA and DNA have been quantitatively addressed.

TL;DR: In this article , the authors synthesized nitrogen-doped carbon dots (N-CDs) with remarkable photodynamic antibacterial properties by a hydrothermal method, and the composite film was prepared by solvent casting method, compounding N-CD with chitosan (CS).